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H2-DMb2 Gene Detail
Summary
  • Symbol
    H2-DMb2
  • Name
    histocompatibility 2, class II, locus Mb2
  • Synonyms
    H2-Mb2, H-2Mb2, H2-M beta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95923
    NCBI Gene: 15000
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34362281-34370529 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95923
 protein coding gene Chr17:34362203-34370529 (+)
129S1/SvImJ ENSMUSG00200046335
 protein coding gene Chr17:30065381-30073629 (+)
A/J ENSMUSG00195045395
 protein coding gene Chr17:30930072-30938424 (+)
AKR/J ENSMUSG00220048320
 protein coding gene Chr17:29957717-29966067 (+)
BALB/cJ ENSMUSG00180028720
 protein coding gene Chr17:30318782-30327223 (+)
C3H/HeJ ENSMUSG00175046927
 protein coding gene Chr17:29843897-29852253 (+)
C57BL/6NJ ENSMUSG00215050979
 protein coding gene Chr17:29905559-29913810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021444
 protein coding gene Chr17:30474823-30491775 (+)
CAST/EiJ ENSTCUG00005050369
 protein coding gene Chr17:30889424-30897853 (+)
CBA/J ENSMUSG00210049682
 protein coding gene Chr17:29665996-29674347 (+)
DBA/2J ENSMUSG00185045408
 protein coding gene Chr17:32338071-32346512 (+)
FVB/NJ ENSMUSG00205035510
 protein coding gene Chr17:30196883-30203165 (+)
JF1/MsJ ENSUMUG00000040813
 protein coding gene Chr17:31599763-31608216 (+)
LP/J ENSMUSG00230054159
 protein coding gene Chr17:33463730-33471982 (+)
NOD/ShiLtJ ENSMUSG00190054034
 protein coding gene Chr17:29817665-29826081 (+)
NZO/HlLtJ ENSMUSG00225053764
 protein coding gene Chr17:35508828-35515136 (+)
PWK/PhJ ENSLUMG00010041630
 protein coding gene Chr17:29443819-29456882 (+)
SPRET/EiJ ENSMSPG00010042735
 protein coding gene Chr17:30589657-30595967 (+)
WSB/EiJ ENSIUOG00005046390
 protein coding gene Chr17:30518010-30531097 (+)



Homology
more
  • Human Ortholog
    HLA-DMB, major histocompatibility complex, class II, DM beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DMB, major histocompatibility complex, class II, DM beta
  • Synonyms
    D6S221E, RING7
  • Links
    NCBI Gene ID: 3109
    UniProt: P28068

  • Chr Location
    6p21.32; chr6:32934629-32941054 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    24
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037548 Ensembl Gene Model | MGI Sequence Detail 8249 C57BL/6J ±  kb
transcript ENSMUST00000041982 Ensembl | MGI Sequence Detail 1424 Not Applicable  
polypeptide ENSMUSP00000043526 Ensembl | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    19 Sequences
  • PDB
    1K8I
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR050160 Major Histocompatibility Complex/Immunoglobulin
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR000353 MHC class II, beta chain, N-terminal
Molecular
Reagents
less
  • All nucleic 30
    Genomic 5
    cDNA 25

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10407, MGD-MRK-10519
References
more
  • Summaries
    All 36
    Gene Ontology 10
    Phenotypes 1
  • Earliest
    J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory