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H2-M5 Gene Detail
Summary
  • Symbol
    H2-M5
  • Name
    histocompatibility 2, M region locus 5
  • Synonyms
    CRW2, D130003B22Rik, H-2M5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95917
    NCBI Gene: 240095
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37294953-37300429 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95917
 protein coding gene Chr17:37294677-37308847 (-)
129S1/SvImJ ENSMUSG00200050227
 protein coding gene Chr17:32752253-32754901 (-)
A/J ENSMUSG00195045577
 protein coding gene Chr17:33961016-33963664 (-)
AKR/J ENSMUSG00220035454
 protein coding gene Chr17:32693635-32696279 (-)
BALB/cJ ENSMUSG00180029078
 protein coding gene Chr17:33441842-33444489 (-)
C3H/HeJ ENSMUSG00175038320
 protein coding gene Chr17:32634164-32636808 (-)
C57BL/6NJ ENSMUSG00215051137
 protein coding gene Chr17:32596097-32598747 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021563
 protein coding gene Chr17:33979350-33984765 (-)
CAST/EiJ ENSTCUG00005051175
 protein coding gene Chr17:33832370-33835009 (-)
CBA/J ENSMUSG00210040911
 protein coding gene Chr17:32370392-32373036 (-)
DBA/2J ENSMUSG00185042499
 protein coding gene Chr17:35422784-35425431 (-)
FVB/NJ ENSMUSG00205022886
 protein coding gene Chr17:32955947-32958595 (-)
JF1/MsJ ENSUMUG00000056789
 protein coding gene Chr17:34365093-34367747 (-)
LP/J ENSMUSG00230054420
 protein coding gene Chr17:36547110-36549757 (-)
NOD/ShiLtJ ENSMUSG00190034933
 protein coding gene Chr17:32636228-32638876 (-)
NZO/HlLtJ ENSMUSG00225052143
 protein coding gene Chr17:38503229-38505866 (-)
PWK/PhJ ENSLUMG00010030956
 protein coding gene Chr17:32248108-32250749 (-)
SPRET/EiJ ENSMSPG00010031717
 protein coding gene Chr17:33504659-33507322 (-)
WSB/EiJ ENSIUOG00005048623
 protein coding gene Chr17:33463623-33466261 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024459 Ensembl Gene Model | MGI Sequence Detail 5477 C57BL/6J ±  kb
    transcript ENSMUST00000169189 Ensembl | MGI Sequence Detail 1170 Not Applicable  
    polypeptide ENSMUSP00000131365 Ensembl | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR050208 Antigen-presenting and immune regulatory MHC class I-related
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 10
      cDNA 3
      Primer pair 1
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10402, MGD-MRK-10513, MGI:3036265
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 14
    • Earliest
      J:13181 Wang CR, et al., Organization and structure of the H-2M4-M8 class I genes in the mouse major histocompatibility complex. Immunogenetics. 1993;38(4):258-71
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory