About   Help   FAQ
Gbx1 Gene Detail
Summary
  • Symbol
    Gbx1
  • Name
    gastrulation brain homeobox 1
  • Synonyms
    Gbx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95667
    NCBI Gene: 231044
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24709424-24731846 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    648 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95667
 protein coding gene Chr5:24707755-24732200 (-)
129S1/SvImJ ENSMUSG00200010196
 protein coding gene Chr5:20314606-20338995 (-)
A/J ENSMUSG00195037323
 protein coding gene Chr5:19785725-19810183 (-)
AKR/J ENSMUSG00220035726
 protein coding gene Chr5:19868367-19892823 (-)
BALB/cJ ENSMUSG00180021464
 protein coding gene Chr5:19652709-19677161 (-)
C3H/HeJ ENSMUSG00175046138
 protein coding gene Chr5:21583957-21608414 (-)
C57BL/6NJ ENSMUSG00215040015
 protein coding gene Chr5:20219646-20244099 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027015
 protein coding gene Chr5:19418109-19442940 (-)
CAST/EiJ ENSTCUG00005003341
 protein coding gene Chr5:19788678-19813259 (-)
CBA/J ENSMUSG00210036214
 protein coding gene Chr5:20623242-20647699 (-)
DBA/2J ENSMUSG00185032682
 protein coding gene Chr5:22155163-22179868 (-)
FVB/NJ ENSMUSG00205023809
 protein coding gene Chr5:19375732-19400187 (-)
JF1/MsJ ENSUMUG00000002999
 protein coding gene Chr5:26718061-26742739 (-)
LP/J ENSMUSG00230021295
 protein coding gene Chr5:26596610-26620996 (-)
NOD/ShiLtJ ENSMUSG00190004340
 protein coding gene Chr5:19689540-19713924 (-)
NZO/HlLtJ ENSMUSG00225017042
 protein coding gene Chr5:32005792-32030302 (-)
PWK/PhJ ENSLUMG00010031514
 protein coding gene Chr5:19756698-19781428 (-)
SPRET/EiJ ENSMSPG00010032444
 protein coding gene Chr5:20624394-20646771 (-)
WSB/EiJ ENSIUOG00005041977
 protein coding gene Chr5:22512125-22536629 (-)



Homology
more
  • Human Ortholog
    GBX1, gastrulation brain homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBX1, gastrulation brain homeobox 1
  • Synonyms
    Huh-17
  • Links
    NCBI Gene ID: 2636
    UniProt: Q14549

  • Chr Location
    7q36.1; chr7:151148009-151174745 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    5 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles exhibit abnormal locomotor behavior affecting hindlimbs and neuron abnormalities. Neuronal abnormalities have been reported in some mice for motor neurons and GABAergic neurons and for proprioceptive sensory axons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    82
  • cDNA Data
    9
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231044 NCBI Gene Model | MGI Sequence Detail 22423 C57BL/6J ±  kb
    transcript NM_015739 RefSeq | MGI Sequence Detail 1452 ZRU/MplStud  
    polypeptide P82976 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 11
      Primer pair 3
      Other 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10010, MGD-MRK-10012
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 5
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:389394 Haenraets K, et al., GABAergic Gbx1 neurons of the superficial dorsal horn are critical elements of a spinal circuit for stress-induced analgesia. Neuron. 2026 Mar 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory