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Dlx2 Gene Detail
Summary
  • Symbol
    Dlx2
  • Name
    distal-less homeobox 2
  • Synonyms
    DII A, Dlx-2, Tes-1
Location &
Maps
more
  • Sequence Map
    Chr2:71373752-71377095 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.65 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94902
 protein coding gene Chr2:71373752-71377098 (-)
129S1/SvImJ ENSMUSG00200036414
 protein coding gene Chr2:68433449-68436795 (-)
A/J ENSMUSG00195020245
 protein coding gene Chr2:68578590-68581935 (-)
AKR/J ENSMUSG00220035365
 protein coding gene Chr2:68543301-68546646 (-)
BALB/cJ ENSMUSG00180035981
 protein coding gene Chr2:68532798-68536144 (-)
C3H/HeJ ENSMUSG00175034726
 protein coding gene Chr2:68645961-68649306 (-)
C57BL/6NJ ENSMUSG00215025264
 protein coding gene Chr2:68471071-68474417 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023647
 protein coding gene Chr2:66080707-66084038 (-)
CAST/EiJ ENSTCUG00005009117
 protein coding gene Chr2:67948254-67951605 (-)
CBA/J ENSMUSG00210033589
 protein coding gene Chr2:68692017-68695363 (-)
DBA/2J ENSMUSG00185040591
 protein coding gene Chr2:68527671-68531017 (-)
FVB/NJ ENSMUSG00205033237
 protein coding gene Chr2:67988974-67992319 (-)
JF1/MsJ ENSUMUG00000003936
 protein coding gene Chr2:68188095-68191440 (-)
LP/J ENSMUSG00230020830
 protein coding gene Chr2:70332987-70336333 (-)
NOD/ShiLtJ ENSMUSG00190029125
 protein coding gene Chr2:68611611-68614956 (-)
NZO/HlLtJ ENSMUSG00225014584
 protein coding gene Chr2:78075275-78078621 (-)
PWK/PhJ ENSLUMG00010032043
 protein coding gene Chr2:68422752-68426098 (-)
SPRET/EiJ ENSMSPG00010035862
 protein coding gene Chr2:69811521-69814869 (-)
WSB/EiJ ENSIUOG00005017984
 protein coding gene Chr2:68656565-68659911 (-)



Homology
more
  • Human Ortholog
    DLX2, distal-less homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLX2, distal-less homeobox 2
  • Synonyms
    TES-1, TES1
  • Links
    NCBI Gene ID: 1746
    UniProt: Q07687

  • Chr Location
    2q31.1; chr2:172099438-172102900 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx1 null allele, maxillary molar teeth are missing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2217
  • Tissues
    677
  • cDNA Data
    48
  • Literature Summary
    367
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13392 NCBI Gene Model | MGI Sequence Detail 3344 C57BL/6J ±  kb
    transcript NM_010054 RefSeq | MGI Sequence Detail 2470 ZRU/MplStud  
    polypeptide P40764 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      Genomic 2
      cDNA 56
      Primer pair 19
      Other 49
      Antibodies 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8858, MGD-MRK-8862, MGI:2139313
    References
    more
    • Summaries
      All 460
      Developmental Gene Expression 367
      Gene Ontology 21
      Phenotypes 75
    • Earliest
      J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
    • Latest
      J:390610 Gao S, et al., Epithelial Hedgehog signaling is essential for tooth patterning and enamel formation. Bone. 2026 Jul 28;:118033
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory