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Dcaf8 Gene Detail
Summary
  • Symbol
    Dcaf8
  • Name
    DDB1 and CUL4 associated factor 8
  • Synonyms
    D1Dau35e, D1Ucla4, H326, Wdr42a
  • Feature Type
    protein coding gene
  • IDs
    MGI:91860
    NCBI Gene: 98193
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171975574-172023959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1038 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_91860
 protein coding gene Chr1:171975574-172024572 (+)
129S1/SvImJ ENSMUSG00200044858
 protein coding gene Chr1:169916211-169964775 (+)
A/J ENSMUSG00195046144
 protein coding gene Chr1:169217632-169266199 (+)
AKR/J ENSMUSG00220026856
 protein coding gene Chr1:168948744-168997299 (+)
BALB/cJ ENSMUSG00180041147
 protein coding gene Chr1:169544839-169593409 (+)
C3H/HeJ ENSMUSG00175044471
 protein coding gene Chr1:169555810-169604373 (+)
C57BL/6NJ ENSMUSG00215042855
 protein coding gene Chr1:168933242-168982221 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014887
 protein coding gene Chr1:162421199-162470178 (+)
CAST/EiJ ENSTCUG00005044665
 protein coding gene Chr1:167499552-167547855 (+)
CBA/J ENSMUSG00210035056
 protein coding gene Chr1:169423101-169471629 (+)
DBA/2J ENSMUSG00185028655
 protein coding gene Chr1:173725222-173773745 (+)
FVB/NJ ENSMUSG00205037851
 protein coding gene Chr1:168395602-168444794 (+)
JF1/MsJ ENSUMUG00000013456
 protein coding gene Chr1:172649197-172698200 (+)
LP/J ENSMUSG00230025963
 protein coding gene Chr1:173320940-173374737 (+)
NOD/ShiLtJ ENSMUSG00190037334
 protein coding gene Chr1:169231278-169279842 (+)
NZO/HlLtJ ENSMUSG00225003140
 protein coding gene Chr1:176900917-176954719 (+)
PWK/PhJ ENSLUMG00010033234
 protein coding gene Chr1:168184222-168232788 (+)
SPRET/EiJ ENSMSPG00010044649
 protein coding gene Chr1:171540414-171588700 (+)
WSB/EiJ ENSIUOG00005038798
 protein coding gene Chr1:168560308-168609398 (+)



Homology
more
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
  • Synonyms
    GAN2, H326, WDR42A
  • Links
    NCBI Gene ID: 50717
    UniProt: Q5TAQ9

  • Chr Location
    1q23.2; chr1:160215715-160263388 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DCAF8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    18
  • cDNA Data
    162
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98193 NCBI Gene Model | MGI Sequence Detail 48386 C57BL/6J ±  kb
    transcript NM_001421210 RefSeq | MGI Sequence Detail 4642 ZRU/MplStud  
    polypeptide Q8N7N5 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 196
      Genomic 25
      cDNA 166
      Primer pair 4
      Other 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-5719, MGI:1347003, MGI:1888988, MGI:2138088, MGI:2138099, MGI:2138429, MGI:2138650
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory