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Lsm2 Gene Detail
Summary
  • Symbol
    Lsm2
  • Name
    LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  • Synonyms
    D17H6S56E-2, D17H6S56E2, Dmapl, Dmpkap, G7b, MGC:13889, Sm-X5, SmX5, snRNP
  • Feature Type
    protein coding gene
  • IDs
    MGI:90676
    NCBI Gene: 27756
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35200838-35204867 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.52 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_90676
 protein coding gene Chr17:35200830-35204867 (+)
129S1/SvImJ ENSMUSG00200049327
 protein coding gene Chr17:30903777-30910027 (+)
A/J ENSMUSG00195041692
 protein coding gene Chr17:31803938-31810188 (+)
AKR/J ENSMUSG00220050096
 protein coding gene Chr17:30832618-30838868 (+)
BALB/cJ ENSMUSG00180039875
 protein coding gene Chr17:31173808-31180058 (+)
C3H/HeJ ENSMUSG00175034824
 protein coding gene Chr17:30718725-30724975 (+)
C57BL/6NJ ENSMUSG00215051569
 protein coding gene Chr17:30743987-30750237 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021490
 protein coding gene Chr17:31725205-31729206 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210047190
 protein coding gene Chr17:30540844-30547094 (+)
DBA/2J ENSMUSG00185051274
 protein coding gene Chr17:33193058-33199308 (+)
FVB/NJ ENSMUSG00205030423
 protein coding gene Chr17:31062409-31068659 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230054605
 protein coding gene Chr17:34302033-34308283 (+)
NOD/ShiLtJ ENSMUSG00190052696
 protein coding gene Chr17:30663314-30669565 (+)
NZO/HlLtJ ENSMUSG00225054795
 protein coding gene Chr17:36314970-36321221 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010033231
 protein coding gene Chr17:31467676-31471690 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    LSM2, LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LSM2, LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  • Synonyms
    C6orf28, G7B, snRNP, YBL026W
  • Links
    NCBI Gene ID: 57819
    UniProt: Q9Y333

  • Chr Location
    6p21.33; chr6:31797392-31806987 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    91
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007050 Ensembl Gene Model | MGI Sequence Detail 4030 C57BL/6J ±  kb
transcript ENSMUST00000007266 Ensembl | MGI Sequence Detail 873 Not Applicable  
polypeptide ENSMUSP00000007266 Ensembl | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    Genomic 3
    cDNA 92

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-37476, MGD-MRK-4483, MGD-MRK-4484, MGI:108432
References
more
  • Summaries
    All 57
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:4064 Olavesen MG, et al., Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs. Immunogenetics. 1993;37(5):394-6
  • Latest
    J:390880 Zhu W, et al., Lsm2 is critical to club cell proliferation and its inhibition aggravates COPD progression. Respir Res. 2025 Feb 28;26(1):71
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory