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Unc5b Gene Detail
Summary
  • Symbol
    Unc5b
  • Name
    unc-5 netrin receptor B
  • Synonyms
    6330415E02Rik, D10Bwg0792e, Unc5h2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894703
    NCBI Gene: 107449
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:60598373-60667360 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 31.52 cM, cytoband B4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1775 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894703
 protein coding gene Chr10:60598372-60667360 (-)
129S1/SvImJ ENSMUSG00200024988
 protein coding gene Chr10:57264171-57333170 (-)
A/J ENSMUSG00195026621
 protein coding gene Chr10:57576643-57645648 (-)
AKR/J ENSMUSG00220040370
 protein coding gene Chr10:57268803-57337814 (-)
BALB/cJ ENSMUSG00180024421
 protein coding gene Chr10:57618933-57687952 (-)
C3H/HeJ ENSMUSG00175025045
 protein coding gene Chr10:57471410-57540415 (-)
C57BL/6NJ ENSMUSG00215027927
 protein coding gene Chr10:57217069-57286067 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015359
 protein coding gene Chr10:55235347-55304558 (-)
CAST/EiJ ENSTCUG00005026300
 protein coding gene Chr10:57266229-57334986 (-)
CBA/J ENSMUSG00210029960
 protein coding gene Chr10:57349733-57418736 (-)
DBA/2J ENSMUSG00185041879
 protein coding gene Chr10:57696486-57765482 (-)
FVB/NJ ENSMUSG00205022223
 protein coding gene Chr10:57369387-57438386 (-)
JF1/MsJ ENSUMUG00000018994
 protein coding gene Chr10:58933752-59002721 (-)
LP/J ENSMUSG00230021873
 protein coding gene Chr10:59499676-59568661 (-)
NOD/ShiLtJ ENSMUSG00190032097
 protein coding gene Chr10:57682315-57751314 (-)
NZO/HlLtJ ENSMUSG00225043559
 protein coding gene Chr10:63780607-63849595 (-)
PWK/PhJ ENSLUMG00010020700
 protein coding gene Chr10:57288050-57356981 (-)
SPRET/EiJ ENSMSPG00010024565
 protein coding gene Chr10:58888723-58954924 (-)
WSB/EiJ ENSIUOG00005038317
 protein coding gene Chr10:57253812-57322773 (-)



Homology
more
  • Human Ortholog
    UNC5B, unc-5 netrin receptor B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNC5B, unc-5 netrin receptor B
  • Synonyms
    p53RDL1, UNC5H2
  • Links
    NCBI Gene ID: 219699
    UniProt: Q8IZJ1

  • Chr Location
    10q22.1; chr10:71212523-71302885 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a severely hypomorphic allele exhibit background sensitive lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1126
  • Tissues
    203
  • cDNA Data
    55
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107449 NCBI Gene Model | MGI Sequence Detail 68988 C57BL/6J ±  kb
    transcript NM_029770 RefSeq | MGI Sequence Detail 5884 ZRU/MplStud  
    polypeptide Q8K1S3 UniProt | EBI | MGI Sequence Detail 945 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 57
      Primer pair 7
      Other 3
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34085, MGI:106392, MGI:1924103
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 51
      Gene Ontology 15
      Phenotypes 39
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:385381 Li Y, et al., Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity. Adv Sci (Weinh). 2026 Jan;13(4):e01066
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory