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Bach2 Gene Detail
Summary
  • Symbol
    Bach2
  • Name
    BTB and CNC homology, basic leucine zipper transcription factor 2
  • Synonyms
    E030004N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894679
    NCBI Gene: 12014
  • Alliance
    genome feature page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:32238804-32586108 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.02 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9147 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894679
 protein coding gene Chr4:32238413-32586109 (+)
129S1/SvImJ ENSMUSG00200012113
 protein coding gene Chr4:28938709-29288060 (+)
A/J ENSMUSG00195000175
 protein coding gene Chr4:29457978-29807376 (+)
AKR/J ENSMUSG00220014426
 protein coding gene Chr4:29250295-29599703 (+)
BALB/cJ ENSMUSG00180000140
 protein coding gene Chr4:28961111-29310495 (+)
C3H/HeJ ENSMUSG00175002285
 protein coding gene Chr4:29423017-29772165 (+)
C57BL/6NJ ENSMUSG00215000790
 protein coding gene Chr4:29037867-29386708 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025862
 protein coding gene Chr4:26689179-27035263 (+)
CAST/EiJ ENSTCUG00005000193
 protein coding gene Chr4:28896431-29249655 (+)
CBA/J ENSMUSG00210004211
 protein coding gene Chr4:29147660-29496816 (+)
DBA/2J ENSMUSG00185000247
 protein coding gene Chr4:29220110-29569238 (+)
FVB/NJ ENSMUSG00205000364
 protein coding gene Chr4:28805239-29154385 (+)
JF1/MsJ ENSUMUG00000001456
 protein coding gene Chr4:29258073-29613830 (+)
LP/J ENSMUSG00230000870
 protein coding gene Chr4:32509377-32858379 (+)
NOD/ShiLtJ ENSMUSG00190000257
 protein coding gene Chr4:29144472-29493618 (+)
NZO/HlLtJ ENSMUSG00225008491
 protein coding gene Chr4:36452662-36801461 (+)
PWK/PhJ ENSLUMG00010007452
 protein coding gene Chr4:28706827-29058613 (+)
SPRET/EiJ ENSMSPG00010002355
 protein coding gene Chr4:29615165-29885904 (+)
WSB/EiJ ENSIUOG00005004553
 protein coding gene Chr4:28944666-29293938 (+)



Homology
more
  • Human Ortholog
    BACH2, BACH transcriptional regulator 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BACH2, BACH transcriptional regulator 2
  • Synonyms
    BTBD25, IMD60
  • Links
    NCBI Gene ID: 60468
    UniProt: Q9BYV9

  • Chr Location
    6q15; chr6:89926528-90296923 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BACH2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 6 alleles in 6 genetic backgrounds
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired B cell differentiation and reduced B cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    136
  • cDNA Data
    58
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040270 Ensembl Gene Model | MGI Sequence Detail 347305 C57BL/6J ±  kb
    transcript ENSMUST00000108180 Ensembl | MGI Sequence Detail 8882 Not Applicable  
    polypeptide ENSMUSP00000103815 Ensembl | MGI Sequence Detail 839 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000004618 transcription regulator protein BACH2
      (term hierarchy)
    • InterPro Domains
      IPR043321 BACH, basic leucine zipper (bZIP) domain
      IPR004827 Basic-leucine zipper domain
      IPR004826 Basic leucine zipper domain, Maf-type
      IPR046347 Basic-leucine zipper domain superfamily
      IPR000210 BTB/POZ domain
      IPR047167 Nuclear Factor Erythroid-derived 2-like
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
      IPR050457 Zinc finger and BTB domain-containing
    • GlyGen
      P97303 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 59
      Primer pair 1
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442959
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 69
    • Earliest
      J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
    • Latest
      J:391502 Wang J, et al., BACH2 controls ILC3 function via PPARgamma-dependent mitochondrial metabolism. J Exp Med. 2026 Jun 1;223(6):e20251918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory