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Plscr1 Gene Detail
Summary
  • Symbol
    Plscr1
  • Name
    phospholipid scramblase 1
  • Synonyms
    MmTRA1a, MmTRA1b, MuPLSCR2, NOR1, TRA1, Tras1, Tras2
  • Feature Type
    protein coding gene
  • IDs
    MGI:893575
    NCBI Gene: 22038
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:92132265-92154034 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 48.35 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    892 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893575
 protein coding gene Chr9:92131803-92154331 (+)
129S1/SvImJ ENSMUSG00200005067
 protein coding gene Chr9:89256626-89279162 (+)
A/J ENSMUSG00195006993
 protein coding gene Chr9:88511229-88533769 (+)
AKR/J ENSMUSG00220019652
 protein coding gene Chr9:88891831-88914359 (+)
BALB/cJ ENSMUSG00180007036
 protein coding gene Chr9:88836967-88859505 (+)
C3H/HeJ ENSMUSG00175004380
 protein coding gene Chr9:89148359-89170895 (+)
C57BL/6NJ ENSMUSG00215008073
 protein coding gene Chr9:89144013-89166540 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032523
 protein coding gene Chr9:88079600-88102599 (+)
CAST/EiJ ENSTCUG00005003720
 protein coding gene Chr9:89068468-89090887 (+)
CBA/J ENSMUSG00210005457
 protein coding gene Chr9:89023121-89045438 (+)
DBA/2J ENSMUSG00185001649
 protein coding gene Chr9:89214730-89236865 (+)
FVB/NJ ENSMUSG00205004546
 protein coding gene Chr9:89350647-89372785 (+)
JF1/MsJ ENSUMUG00000027865
 protein coding gene Chr9:88927872-88950183 (+)
LP/J ENSMUSG00230008211
 protein coding gene Chr9:89362622-89385153 (+)
NOD/ShiLtJ ENSMUSG00190010768
 protein coding gene Chr9:88806411-88828939 (+)
NZO/HlLtJ ENSMUSG00225015650
 protein coding gene Chr9:89509910-89532226 (+)
PWK/PhJ ENSLUMG00010002914
 protein coding gene Chr9:88896840-88919210 (+)
SPRET/EiJ ENSMSPG00010002243
 protein coding gene Chr9:90656412-90677130 (+)
WSB/EiJ ENSIUOG00005003557
 protein coding gene Chr9:88267283-88289810 (+)



Homology
more
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Synonyms
    MMTRA1B
  • Links
    NCBI Gene ID: 5359
    UniProt: O15162

  • Chr Location
    3q24; chr3:146511858-146544862 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a grossly normal phenotype although there are hematopoietic abnormalities in newborn mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    625
  • Tissues
    4
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22038 NCBI Gene Model | MGI Sequence Detail 21770 C57BL/6J ±  kb
    transcript NM_001410453 RefSeq | MGI Sequence Detail 1607 C57BL/6  
    polypeptide Q9JJ00 UniProt | EBI | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:893574
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 1
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:39827 Kasukabe T, et al., TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines. Blood. 1997 Apr 15;89(8):2975-85
    • Latest
      J:371379 Caputo M, et al., Phospholipid Scramblase 1 Controls Efficient Neurotransmission and Synaptic Vesicle Retrieval at Cerebellar Synapses. J Neurosci. 2024 Jul 3;44(27)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory