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Sfrp1 Gene Detail
Summary
  • Symbol
    Sfrp1
  • Name
    secreted frizzled-related protein 1
  • Synonyms
    2210415K03Rik, sFRP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:892014
    NCBI Gene: 20377
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23901518-23939648 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1097 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892014
 protein coding gene Chr8:23901401-23939648 (+)
129S1/SvImJ ENSMUSG00200028515
 protein coding gene Chr8:18944241-18982280 (+)
A/J ENSMUSG00195039391
 protein coding gene Chr8:19495862-19533909 (+)
AKR/J ENSMUSG00220032460
 protein coding gene Chr8:19127924-19165969 (+)
BALB/cJ ENSMUSG00180024059
 protein coding gene Chr8:19020477-19058514 (+)
C3H/HeJ ENSMUSG00175037697
 protein coding gene Chr8:19091856-19129907 (+)
C57BL/6NJ ENSMUSG00215023531
 protein coding gene Chr8:18983149-19021310 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030908
 protein coding gene Chr8:17935006-17973327 (+)
CAST/EiJ ENSTCUG00005018780
 protein coding gene Chr8:19310018-19348224 (+)
CBA/J ENSMUSG00210040154
 protein coding gene Chr8:19020020-19058054 (+)
DBA/2J ENSMUSG00185035419
 protein coding gene Chr8:24829124-24867171 (+)
FVB/NJ ENSMUSG00205020954
 protein coding gene Chr8:18518113-18556144 (+)
JF1/MsJ ENSUMUG00000011293
 protein coding gene Chr8:26699608-26737923 (+)
LP/J ENSMUSG00230010171
 protein coding gene Chr8:28575900-28614451 (+)
NOD/ShiLtJ ENSMUSG00190037182
 protein coding gene Chr8:19053507-19091539 (+)
NZO/HlLtJ ENSMUSG00225020098
 protein coding gene Chr8:32198091-32236233 (+)
PWK/PhJ ENSLUMG00010026968
 protein coding gene Chr8:19065770-19104056 (+)
SPRET/EiJ ENSMSPG00010013969
 protein coding gene Chr8:19312410-19350892 (+)
WSB/EiJ ENSIUOG00005019530
 protein coding gene Chr8:19752958-19790998 (+)



Homology
more
  • Human Ortholog
    SFRP1, secreted frizzled related protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFRP1, secreted frizzled related protein 1
  • Synonyms
    FRP, FRP-1, FRP1, FrzA, SARP2
  • Links
    NCBI Gene ID: 6422
    UniProt: Q8N474

  • Chr Location
    8p11.21; chr8:41261956-41309511 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    178
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1296
  • Tissues
    440
  • cDNA Data
    172
  • Literature Summary
    125
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031548 Ensembl Gene Model | MGI Sequence Detail 38131 C57BL/6J ±  kb
    transcript ENSMUST00000033952 Ensembl | MGI Sequence Detail 4372 Not Applicable  
    polypeptide ENSMUSP00000033952 Ensembl | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 202
      cDNA 176
      Primer pair 20
      Other 6
      Antibodies 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 125
      Gene Ontology 29
      Phenotypes 43
    • Earliest
      J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
    • Latest
      J:373718 Firulli BA, et al., Hand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects. Development. 2025 Oct 1;152(19):dev204963
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory