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Ywhaq Gene Detail
Summary
  • Symbol
    Ywhaq
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  • Synonyms
    14-3-3 tau, 14-3-3 theta, 2700028P07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:891963
    NCBI Gene: 22630
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:21440330-21467437 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    627 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891963
 protein coding gene Chr12:21440072-21467638 (-)
129S1/SvImJ ENSMUSG00200022326
 protein coding gene Chr12:15698460-15725972 (-)
A/J ENSMUSG00195018061
 protein coding gene Chr12:16926238-16955457 (+)
AKR/J ENSMUSG00220012720
 protein coding gene Chr13:9807862-9809401 (-)
AKR/J ENSMUSG00220026303
 protein coding gene Chr12:15391823-15421059 (-)
BALB/cJ ENSMUSG00180008846
 protein coding gene Chr12:16311084-16340300 (-)
C3H/HeJ ENSMUSG00175005540
 protein coding gene Chr12:15441497-15469010 (-)
C57BL/6NJ ENSMUSG00215004969
 protein coding gene Chr12:15341027-15368594 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017643
 protein coding gene Chr12:17833911-17866051 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210007480
 protein coding gene Chr12:16851558-16879070 (-)
DBA/2J ENSMUSG00185003688
 protein coding gene Chr12:15676262-15703773 (-)
FVB/NJ ENSMUSG00205001265
 protein coding gene Chr12:15232229-15259740 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230021248
 protein coding gene Chr12:18835280-18862801 (-)
NOD/ShiLtJ ENSMUSG00190007894
 protein coding gene Chr12:269666-297178 (-)
NZO/HlLtJ ENSMUSG00225033616
 protein coding gene Chr12:20939844-20967364 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010002766
 protein coding gene Chr12:16664672-16694144 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    YWHAQ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAQ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  • Synonyms
    14-3-3, 1C5, HS1
  • Links
    NCBI Gene ID: 10971
    UniProt: P27348

  • Chr Location
    2p25.1; chr2:9583967-9639472 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trap allele are developmentally delayed and die by E14 with no specific cardiac defects; however, heterozygotes develop larger myocardial infarctions with increased post-infarction cardiac remodeling while cultured cardiomyocytes are sensitized to proapoptotic stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    101
  • cDNA Data
    33
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22630 NCBI Gene Model | MGI Sequence Detail 27108 C57BL/6J ±  kb
    transcript NM_011739 RefSeq | MGI Sequence Detail 2110 C57BL/6  
    polypeptide P68254 UniProt | EBI | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 33
      Primer pair 5
      Other 2
      Antibodies 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1924055, MGI:2144732, MGI:2144953, MGI:2145131
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 11
      Gene Ontology 15
      Phenotypes 14
    • Earliest
      J:33414 Papin C, et al., Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system. Oncogene. 1996 May 16;12(10):2213-21
    • Latest
      J:377229 Wang B, et al., 14-3-3theta phosphorylation exacerbates alpha-synuclein aggregation and toxicity. Neurobiol Dis. 2025 Jan 11;206:106801
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory