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Cs Gene Detail
Summary
  • Symbol
    Cs
  • Name
    citrate synthase
  • Synonyms
    2610511A05Rik, 9030605P22Rik, ahl4, Cis
  • Feature Type
    protein coding gene
  • IDs
    MGI:88529
    NCBI Gene: 12974
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128173603-128198348 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    545 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88529
 protein coding gene Chr10:128173596-128198351 (+)
129S1/SvImJ ENSMUSG00200010527
 protein coding gene Chr10:124527789-124552533 (+)
A/J ENSMUSG00195013335
 protein coding gene Chr10:124991038-125015786 (+)
AKR/J ENSMUSG00220004763
 protein coding gene Chr10:124596519-124621459 (+)
BALB/cJ ENSMUSG00180010411
 protein coding gene Chr10:124982005-125006753 (+)
C3H/HeJ ENSMUSG00175006003
 protein coding gene Chr10:124981132-125006069 (+)
C57BL/6NJ ENSMUSG00215010385
 protein coding gene Chr10:124592023-124616770 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015932
 protein coding gene Chr10:120700667-120725286 (+)
CAST/EiJ ENSTCUG00005034544
 protein coding gene Chr10:123979274-124003785 (+)
CBA/J ENSMUSG00210009150
 protein coding gene Chr10:124805346-124830283 (+)
DBA/2J ENSMUSG00185025185
 protein coding gene Chr10:124959359-124984105 (+)
FVB/NJ ENSMUSG00205023820
 protein coding gene Chr10:124201094-124225617 (+)
JF1/MsJ ENSUMUG00000015396
 protein coding gene Chr10:126269545-126294033 (+)
LP/J ENSMUSG00230025200
 protein coding gene Chr10:126881547-126906480 (+)
NOD/ShiLtJ ENSMUSG00190014195
 protein coding gene Chr10:125023005-125047749 (+)
NZO/HlLtJ ENSMUSG00225035446
 protein coding gene Chr10:131083923-131108668 (+)
PWK/PhJ ENSLUMG00010008979
 protein coding gene Chr10:124720522-124745045 (+)
SPRET/EiJ ENSMSPG00010030092
 protein coding gene Chr10:126684552-126709202 (+)
WSB/EiJ ENSIUOG00005008017
 protein coding gene Chr10:124597709-124622493 (+)



Homology
more
  • Human Ortholog
    CS, citrate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CS, citrate synthase
  • Links
    NCBI Gene ID: 1431
    UniProt: O75390

  • Chr Location
    12q13.3; chr12:56271699-56300391 (-)  GRCh38
  • MGI Vertebrate Homology
    Cs stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: CS
  • Gene Tree
    Cs
Human Diseases
more
  • Diseases
    2 with human CS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation exhibit hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    107
  • cDNA Data
    14
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005683 Ensembl Gene Model | MGI Sequence Detail 24746 C57BL/6J ±  kb
    transcript ENSMUST00000005826 Ensembl | MGI Sequence Detail 2926 Not Applicable  
    polypeptide ENSMUSP00000005826 Ensembl | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1986, MGD-MRK-2184, MGI:1915151, MGI:1918798, MGI:2143907, MGI:3514039
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 17
      Gene Ontology 17
      Phenotypes 18
    • Earliest
      J:4573 Cox DR, et al., Comparative gene mapping in man and mouse: assignment of the gene for citrate synthase (Cis) to mouse Chromosome 10. Cytogenet Cell Genet. 1982;32:259 (Abstr.)
    • Latest
      J:381869 Courtney Y, et al., Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development. Nat Neurosci. 2025 Jul;28(7):1446-1459
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory