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Crygf Gene Detail
Summary
  • Symbol
    Crygf
  • Name
    crystallin, gamma F
  • Synonyms
    3110001K11Rik, Cryg-2, DGcry-2, Len-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88526
    NCBI Gene: 12969
  • Member of
    Cryg cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65965679-65967466 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.31 cM, cytoband C3
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88526
 protein coding gene Chr1:65965679-65967470 (+)
129S1/SvImJ ENSMUSG00200004392
 protein coding gene Chr1:63497556-63499342 (+)
A/J ENSMUSG00195029257
 protein coding gene Chr1:63025566-63027352 (+)
AKR/J ENSMUSG00220036345
 protein coding gene Chr1:63138908-63140717 (+)
BALB/cJ ENSMUSG00180030497
 protein coding gene Chr1:63294611-63296398 (+)
C3H/HeJ ENSMUSG00175000793
 protein coding gene Chr1:63413786-63415572 (+)
C57BL/6NJ ENSMUSG00215020797
 protein coding gene Chr1:63320368-63322155 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014223
 protein coding gene Chr1:59838886-59840677 (+)
CAST/EiJ ENSTCUG00005020278
 protein coding gene Chr1:63139676-63141483 (+)
CBA/J ENSMUSG00210003169
 protein coding gene Chr1:63095051-63096837 (+)
DBA/2J ENSMUSG00185004801
 protein coding gene Chr1:64212217-64214003 (+)
FVB/NJ ENSMUSG00205012428
 protein coding gene Chr1:63035781-63037567 (+)
JF1/MsJ ENSUMUG00000003062
 protein coding gene Chr1:63120612-63122399 (+)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190013570
 protein coding gene Chr1:63276745-63278531 (+)
NZO/HlLtJ ENSMUSG00225001127
 protein coding gene Chr1:67391575-67393362 (+)
PWK/PhJ ENSLUMG00010007133
 protein coding gene Chr1:62672899-62674691 (+)
SPRET/EiJ ENSMSPG00010018741
 protein coding gene Chr1:64711542-64713362 (+)
WSB/EiJ ENSIUOG00005026692
 protein coding gene Chr1:62958313-62960114 (+)



Homology
more
  • Human Ortholog
    CRYGD, crystallin gamma D
  • Vertebrate Orthologs
    13
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYGD, crystallin gamma D
  • Synonyms
    CACA, CCA3, CCP, CRYG4, cry-g-D, CTRCT4, PCC
  • Links
    NCBI Gene ID: 1421
    UniProt: P07320

  • Chr Location
    2q33.3; chr2:208121607-208124524 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CRYGD associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a chemically-induced single point mutation exhibit homogeneous cataracts while heterozygotes display less severe rays and concentric circles of lens opacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    648
  • Tissues
    11
  • cDNA Data
    87
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025945 Ensembl Gene Model | MGI Sequence Detail 1788 C57BL/6J ±  kb
    transcript ENSMUST00000027082 Ensembl | MGI Sequence Detail 627 Not Applicable  
    polypeptide ENSMUSP00000027082 Ensembl | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 3
      cDNA 88
      Primer pair 6
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2171, MGD-MRK-2181, MGD-MRK-8837, MGI:1916514
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 14
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory