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Cdh3 Gene Detail
Summary
  • Symbol
    Cdh3
  • Name
    cadherin 3
  • Synonyms
    Cadp, Pcad, P-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88356
    NCBI Gene: 12560
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr8:107237484-107283543 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.16 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1375 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88356
 protein coding gene Chr8:107237484-107283929 (+)
129S1/SvImJ ENSMUSG00200012167
 protein coding gene Chr8:101517420-101563836 (+)
A/J ENSMUSG00195017142
 protein coding gene Chr8:101839990-101886417 (+)
AKR/J ENSMUSG00220014019
 protein coding gene Chr8:101978977-102025401 (+)
BALB/cJ ENSMUSG00180021417
 protein coding gene Chr8:101845774-101892192 (+)
C3H/HeJ ENSMUSG00175021514
 protein coding gene Chr8:101902841-101949264 (+)
C57BL/6NJ ENSMUSG00215020365
 protein coding gene Chr8:101516794-101563207 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031520
 protein coding gene Chr8:97634585-97681154 (+)
CAST/EiJ ENSTCUG00005030615
 protein coding gene Chr8:101273106-101320244 (+)
CBA/J ENSMUSG00210030293
 protein coding gene Chr8:101830157-101876571 (+)
DBA/2J ENSMUSG00185005101
 protein coding gene Chr8:107938898-107985318 (+)
FVB/NJ ENSMUSG00205015411
 protein coding gene Chr8:100814516-100860935 (+)
JF1/MsJ ENSUMUG00000010413
 protein coding gene Chr8:110272072-110318485 (+)
LP/J ENSMUSG00230034387
 protein coding gene Chr8:111619267-111665681 (+)
NOD/ShiLtJ ENSMUSG00190018504
 protein coding gene Chr8:101965163-102011579 (+)
NZO/HlLtJ ENSMUSG00225022483
 protein coding gene Chr8:114969816-115016238 (+)
PWK/PhJ ENSLUMG00010028533
 protein coding gene Chr8:101757149-101803659 (+)
SPRET/EiJ ENSMSPG00010034182
 protein coding gene Chr8:103821490-103871753 (+)
WSB/EiJ ENSIUOG00005029825
 protein coding gene Chr8:102634656-102680988 (+)



Homology
more
  • Human Ortholog
    CDH3, cadherin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH3, cadherin 3
  • Synonyms
    CDHP, HJMD, PCAD
  • Links
    NCBI Gene ID: 1001
    UniProt: P22223

  • Chr Location
    16q22.1; chr16:68636189-68733771 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CDH3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in precocious development of mammary glands in virgin 10-week old females. Aged virgin females (24 weeks) exhibit alveolar hyperplasia, ductal dysplasia, and extensive lymphocyte infiltration of the mammary glands.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1035
  • Tissues
    323
  • cDNA Data
    64
  • Literature Summary
    121
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12560 NCBI Gene Model | MGI Sequence Detail 46060 C57BL/6J ±  kb
    transcript NM_001037809 RefSeq | MGI Sequence Detail 4037 ZRU/MplStud  
    polypeptide P10287 UniProt | EBI | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 10
      cDNA 64
      Primer pair 8
      Other 4
      Antibodies 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13170, MGD-MRK-1723, MGD-MRK-1883, MGI:2142516
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 121
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:31206 Nose A, et al., A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol. 1986 Dec;103(6 Pt 2):2649-58
    • Latest
      J:383221 Tam HT, et al., Hyperinnervation inhibits organ-level regeneration in mammalian skin. Cell. 2026 Mar 20;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory