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Cd72 Gene Detail
Summary
  • Symbol
    Cd72
  • Name
    CD72 antigen
  • Synonyms
    Ly-19, Ly-32, Lyb-2, Ly-m19
  • Feature Type
    protein coding gene
  • IDs
    MGI:88345
    NCBI Gene: 12517
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43447724-43454708 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.04 cM
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88345
 protein coding gene Chr4:43446462-43454708 (-)
129S1/SvImJ ENSMUSG00200005246
 protein coding gene Chr4:39481702-39489856 (-)
A/J ENSMUSG00195002992
 protein coding gene Chr4:39954429-39962586 (-)
AKR/J ENSMUSG00220035055
 protein coding gene Chr4:39642656-39650979 (-)
BALB/cJ ENSMUSG00180020453
 protein coding gene Chr4:39541186-39549343 (-)
C3H/HeJ ENSMUSG00175021585
 protein coding gene Chr4:39685518-39693674 (-)
C57BL/6NJ ENSMUSG00215025355
 protein coding gene Chr4:39466786-39474952 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025935
 protein coding gene Chr4:37536014-37544358 (-)
CAST/EiJ ENSTCUG00005004088
 protein coding gene Chr4:39728202-39736474 (-)
CBA/J ENSMUSG00210007500
 protein coding gene Chr4:39377370-39385803 (-)
DBA/2J ENSMUSG00185006033
 protein coding gene Chr4:39740799-39749232 (-)
FVB/NJ ENSMUSG00205016054
 protein coding gene Chr4:38984064-38992500 (-)
JF1/MsJ ENSUMUG00000014733
 protein coding gene Chr4:39978229-39986349 (-)
LP/J ENSMUSG00230037632
 protein coding gene Chr4:43294643-43302809 (-)
NOD/ShiLtJ ENSMUSG00190005057
 protein coding gene Chr4:39600986-39609309 (-)
NZO/HlLtJ ENSMUSG00225006655
 protein coding gene Chr4:47881896-47890065 (-)
PWK/PhJ ENSLUMG00010006385
 protein coding gene Chr4:38979795-38988204 (-)
SPRET/EiJ ENSMSPG00010024284
 protein coding gene Chr4:39918490-39925110 (-)
WSB/EiJ ENSIUOG00005049424
 protein coding gene Chr4:39353191-39368618 (-)



Homology
more
  • Human Ortholog
    CD72, CD72 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD72, CD72 molecule
  • Synonyms
    CD72b, LYB2
  • Links
    NCBI Gene ID: 971
    UniProt: P21854

  • Chr Location
    9p13.3; chr9:35609982-35646857 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    26 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired B cell development and delayed maturation, resulting in reduced numbers of mature B cells and an expansion of pre-B cells. Mice have fewer peripheral mature B-2 cells and more B-1 cells. B cells are hyperproliferative in response to stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    5
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12517 NCBI Gene Model | MGI Sequence Detail 6985 C57BL/6J ±  kb
    transcript NM_001419976 RefSeq | MGI Sequence Detail 1590 ZRU/MplStud  
    polypeptide P21855 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11957, MGD-MRK-11973, MGD-MRK-12012, MGD-MRK-12054, MGD-MRK-1871
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:12065 Sato H, et al., A new alloantigen expressed on B cells: the Lyb-2 system. Immunogenetics. 1976;3:565-572
    • Latest
      J:386812 Ruiz-Corzo B, et al., Deletion of 9p drives B-ALL through heterozygous inactivation of Pax5 and Cd72 in preleukemic cells. JCI Insight. 2026 Apr 8;11(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory