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Cd34 Gene Detail
Summary
  • Symbol
    Cd34
  • Name
    CD34 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88329
    NCBI Gene: 12490
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:194621239-194643587 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    357 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88329
 protein coding gene Chr1:194621127-194643587 (+)
129S1/SvImJ ENSMUSG00200004065
 protein coding gene Chr1:192414448-192436908 (+)
A/J ENSMUSG00195008338
 protein coding gene Chr1:191996998-192019459 (+)
AKR/J ENSMUSG00220004112
 protein coding gene Chr1:191244402-191266864 (+)
BALB/cJ ENSMUSG00180017757
 protein coding gene Chr1:192063958-192086419 (+)
C3H/HeJ ENSMUSG00175021469
 protein coding gene Chr1:192271088-192293549 (+)
C57BL/6NJ ENSMUSG00215015497
 protein coding gene Chr1:191457484-191479944 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015073
 protein coding gene Chr1:185219792-185242779 (+)
CAST/EiJ ENSTCUG00005001912
 protein coding gene Chr1:190022916-190045315 (+)
CBA/J ENSMUSG00210003459
 protein coding gene Chr1:191929891-191952353 (+)
DBA/2J ENSMUSG00185010015
 protein coding gene Chr1:196530658-196553119 (+)
FVB/NJ ENSMUSG00205004390
 protein coding gene Chr1:190899011-190921471 (+)
JF1/MsJ ENSUMUG00000007767
 protein coding gene Chr1:195505726-195528136 (+)
LP/J ENSMUSG00230002170
 protein coding gene Chr1:196033303-196055765 (+)
NOD/ShiLtJ ENSMUSG00190028196
 protein coding gene Chr1:191899934-191922399 (+)
NZO/HlLtJ ENSMUSG00225015830
 protein coding gene Chr1:199792793-199815192 (+)
PWK/PhJ ENSLUMG00010006358
 protein coding gene Chr1:190748646-190771107 (+)
SPRET/EiJ ENSMSPG00010022333
 protein coding gene Chr1:194270427-194292871 (+)
WSB/EiJ ENSIUOG00005004111
 protein coding gene Chr1:191221642-191244040 (+)



Homology
more
  • Human Ortholog
    CD34, CD34 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD34, CD34 molecule
  • Links
    NCBI Gene ID: 947
    UniProt: P28906

  • Chr Location
    1q32.2; chr1:207880972-207911402 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show decreased splenocyte number and hematopoietic defects. Homozygotes for another null allele show reduced eosinophil accumulation after allergen exposure, impaired TPA-induced hair follicle stem cell activation and reduced incidence of chemically-induced skin tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1452
  • Tissues
    434
  • cDNA Data
    124
  • Literature Summary
    216
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12490 NCBI Gene Model | MGI Sequence Detail 22349 C57BL/6J ±  kb
    transcript NM_001111059 RefSeq | MGI Sequence Detail 2498 ZRU/MplStud  
    polypeptide Q64314 UniProt | EBI | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 4
      cDNA 126
      Primer pair 7
      Other 3
      Antibodies 33

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1849, MGI:2138487
    References
    more
    • Summaries
      All 300
      Developmental Gene Expression 216
      Gene Ontology 20
      Phenotypes 28
    • Earliest
      J:2996 Howell SM, et al., Localisation of the gene coding for the haemopoietic stem cell antigen CD34 to chromosome 1q32. Hum Genet. 1991 Sep;87(5):625-7
    • Latest
      J:390324 Hess C, et al., A Unified Developmental Timeline of Pigmented Ocular Tissues in the Mouse Eye. Exp Eye Res. 2026 Jul 22;:111178
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory