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Cbln2 Gene Detail
Summary
  • Symbol
    Cbln2
  • Name
    cerebellin 2 precursor protein
  • Synonyms
    6330593N19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88282
    NCBI Gene: 12405
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Regulated by
    Rr467 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr18:86729235-86736408 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 58.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88282
 protein coding gene Chr18:86727226-86736410 (+)
129S1/SvImJ ENSMUSG00200015234
 protein coding gene Chr18:84016980-84024151 (+)
A/J ENSMUSG00195001286
 protein coding gene Chr18:84022659-84029832 (+)
AKR/J ENSMUSG00220016505
 protein coding gene Chr18:83930230-83937403 (+)
BALB/cJ ENSMUSG00180002489
 protein coding gene Chr18:84574692-84581864 (+)
C3H/HeJ ENSMUSG00175018303
 protein coding gene Chr18:84127092-84134265 (+)
C57BL/6NJ ENSMUSG00215004163
 protein coding gene Chr18:83533706-83540879 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022457
 protein coding gene Chr18:82600040-82607191 (+)
CAST/EiJ ENSTCUG00005005377
 protein coding gene Chr18:83063815-83070978 (+)
CBA/J ENSMUSG00210017802
 protein coding gene Chr18:84067754-84074927 (+)
DBA/2J ENSMUSG00185004198
 protein coding gene Chr18:83970325-83977498 (+)
FVB/NJ ENSMUSG00205012960
 protein coding gene Chr18:83369637-83376811 (+)
JF1/MsJ ENSUMUG00000015559
 protein coding gene Chr18:83831612-83838770 (+)
LP/J ENSMUSG00230016861
 protein coding gene Chr18:86080179-86087350 (+)
NOD/ShiLtJ ENSMUSG00190003289
 protein coding gene Chr18:83785374-83792547 (+)
NZO/HlLtJ ENSMUSG00225023460
 protein coding gene Chr18:85967981-85975152 (+)
PWK/PhJ ENSLUMG00010004030
 protein coding gene Chr18:84224000-84231166 (+)
SPRET/EiJ ENSMSPG00010001278
 protein coding gene Chr18:84716956-84723728 (+)
WSB/EiJ ENSIUOG00005015887
 protein coding gene Chr18:83449305-83456475 (+)



Homology
more
  • Human Ortholog
    CBLN2, cerebellin 2 precursor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBLN2, cerebellin 2 precursor
  • Links
    NCBI Gene ID: 147381
    UniProt: Q8IUK8

  • Chr Location
    18q22.3; chr18:72534118-72638521 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    235 phenotype references
No overt anatomical or neuroanatomical defects are observed in mice homozygous for deletion of this gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1031
  • Tissues
    150
  • cDNA Data
    23
  • Literature Summary
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024647 Ensembl Gene Model | MGI Sequence Detail 7174 C57BL/6J ±  kb
transcript ENSMUST00000122079 Ensembl | MGI Sequence Detail 2549 Not Applicable  
polypeptide ENSMUSP00000113695 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 23
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1785, MGI:2443422
References
more
  • Summaries
    All 283
    Developmental Gene Expression 20
    Diseases 2
    Gene Ontology 13
    Phenotypes 235
  • Earliest
    J:21224 Kavety B, et al., Genomic structure and mapping of precerebellin and a precerebellin-related gene. Brain Res Mol Brain Res. 1994 Nov;27(1):152-6
  • Latest
    J:389086 Zheng B, et al., Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity. Nucleic Acids Res. 2026 Jul 3;54(13)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory