About   Help   FAQ
Anxa2 Gene Detail
Summary
  • Symbol
    Anxa2
  • Name
    annexin A2
  • Synonyms
    36-kDa calelectrin, annexin II, Cal1h, lipocortin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88246
    NCBI Gene: 12306
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:69360978-69399074 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 38.58 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1245 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88246
 protein coding gene Chr9:69360902-69399077 (+)
129S1/SvImJ ENSMUSG00200040831
 protein coding gene Chr9:66449760-66487967 (+)
A/J ENSMUSG00195024737
 protein coding gene Chr9:66227975-66266163 (+)
AKR/J ENSMUSG00220038560
 protein coding gene Chr9:66372416-66410605 (+)
BALB/cJ ENSMUSG00180017515
 protein coding gene Chr9:66347874-66386054 (+)
C3H/HeJ ENSMUSG00175012514
 protein coding gene Chr9:66361350-66399525 (+)
C57BL/6NJ ENSMUSG00215022771
 protein coding gene Chr9:66304259-66342440 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032395
 protein coding gene Chr9:66637322-66676427 (+)
CAST/EiJ ENSTCUG00005028508
 protein coding gene Chr9:66172910-66212297 (+)
CBA/J ENSMUSG00210013722
 protein coding gene Chr9:66442114-66480275 (+)
DBA/2J ENSMUSG00185033418
 protein coding gene Chr9:66465829-66503990 (+)
FVB/NJ ENSMUSG00205017344
 protein coding gene Chr9:66739967-66778135 (+)
JF1/MsJ ENSUMUG00000037464
 protein coding gene Chr9:66486280-66526279 (+)
LP/J ENSMUSG00230024353
 protein coding gene Chr9:66644950-66683156 (+)
NOD/ShiLtJ ENSMUSG00190019718
 protein coding gene Chr9:66568842-66608601 (+)
NZO/HlLtJ ENSMUSG00225044671
 protein coding gene Chr9:66766008-66805989 (+)
PWK/PhJ ENSLUMG00010025957
 protein coding gene Chr9:66437030-66477061 (+)
SPRET/EiJ ENSMSPG00010017542
 protein coding gene Chr9:67527681-67568410 (+)
WSB/EiJ ENSIUOG00005023335
 protein coding gene Chr9:65922684-65960935 (+)



Homology
more
  • Human Ortholog
    ANXA2, annexin A2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANXA2, annexin A2
  • Synonyms
    ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV
  • Links
    NCBI Gene ID: 302
    UniProt: P07355

  • Chr Location
    15q22.2; chr15:60347134-60402883 (-)  GRCh38
  • Human Ortholog
    ANXA2P2, annexin A2 pseudogene 2
  • Synonyms
    ANX2L2, ANX2P2, LPC2B
  • Links
    NCBI Gene ID: 304
    UniProt: A6NMY6

  • Chr Location
    9p13.3; chr9:33624225-33625534 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ANXA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are viable and fertile but suffer from growth deficits, impaired angiogenesis, and increased susceptibility to thrombosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    128
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    693
  • Tissues
    35
  • cDNA Data
    461
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12306 NCBI Gene Model | MGI Sequence Detail 38097 C57BL/6J ±  kb
    transcript NM_001409577 RefSeq | MGI Sequence Detail 1393 ZRU/MplStud  
    polypeptide P07356 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 470
      Genomic 5
      cDNA 461
      Primer pair 1
      Other 3
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1727, MGI:2143302
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 25
      Gene Ontology 26
      Phenotypes 43
    • Earliest
      J:8318 Saris CJ, et al., The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell. 1986 Jul 18;46(2):201-12
    • Latest
      J:387405 Wu P, et al., Muscle-derived ANXA2 promotes hepatic steatosis by activating SREBP1c-mediated de novo lipogenesis. Metabolism. 2026 May 31;:156657
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory