Adk MGI Mouse Gene Detail - MGI:87930

Symbol

Adk
Name

adenosine kinase
Synonyms

2310026J05Rik, 5033405D03Rik, AK, MGC:6593

Feature Type

protein coding gene
IDs

MGI:87930
NCBI Gene: 11534
Alliance

genome feature page
Transcription Start Sites

21 TSS

Sequence Map

Chr14:21102642-21498637 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 11.58 cM, cytoband A2-B
Mapping Data

6 experiments

SNPs within 2kb

10640 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87930	protein coding gene	Chr14:21102622-21498637 (+)
129S1/SvImJ	ENSMUSG00200014530	protein coding gene	Chr14:12889036-13297783 (+)
A/J	ENSMUSG00195019470	protein coding gene	Chr14:13975297-14371347 (+)
AKR/J	ENSMUSG00220024199	protein coding gene	Chr14:13105834-13501882 (+)
BALB/cJ	ENSMUSG00180036416	protein coding gene	Chr14:13070536-13467051 (+)
C3H/HeJ	ENSMUSG00175021240	protein coding gene	Chr14:13131151-13527169 (+)
C57BL/6NJ	ENSMUSG00215021043	protein coding gene	Chr14:13320804-13716834 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019004	protein coding gene	Chr14:13818306-14216501 (+)
CAST/EiJ	ENSTCUG00005029087	protein coding gene	Chr14:13248528-13647816 (+)
CBA/J	ENSMUSG00210025255	protein coding gene	Chr14:13362137-13770846 (+)
DBA/2J	ENSMUSG00185033649	protein coding gene	Chr14:17647198-18055900 (+)
FVB/NJ	ENSMUSG00205033544	protein coding gene	Chr14:13204170-13611262 (+)
JF1/MsJ	ENSUMUG00000038436	protein coding gene	Chr14:24862568-25261061 (+)
LP/J	ENSMUSG00230038263	protein coding gene	Chr14:24928967-25337672 (+)
NOD/ShiLtJ	ENSMUSG00190028659	protein coding gene	Chr14:13361035-13769726 (+)
NZO/HlLtJ	ENSMUSG00225036206	protein coding gene	Chr14:19164556-19558404 (+)
PWK/PhJ	ENSLUMG00010020356	protein coding gene	Chr14:1453670-1851606 (+)
SPRET/EiJ	ENSMSPG00010026071	protein coding gene	Chr14:14990895-15396995 (+)
WSB/EiJ	ENSIUOG00005028760	protein coding gene	Chr14:13179174-13577790 (+)

Human Ortholog

ADK, adenosine kinase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADK, adenosine kinase
Synonyms

AK
Links

HGNC:257

NCBI Gene ID: 132

UniProt: P55263
Chr Location

10q22; chr10:74151191-74709963 (+) GRCh38

MGI Vertebrate Homology

Adk stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ADK
Gene Tree

Adk

Diseases

1 with Adk mouse models; 1 with human ADK associations

Human Disease

Mouse Models

steatotic liver disease

IDs

View 1 model

hypermethioninemia due to adenosine kinase deficiency

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

38 phenotypes from 4 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
1 images
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

90
Endonuclease-mediated

5
Gene trapped

79
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in death before 14 days of age, growth retardation, liver abnormalities, apnea, and impaired temperature regulation.

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All GO Annotations

50
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1134
Tissues

212
cDNA Data

168
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adk

ZFIN adka, adkb

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All Sequences

77
RefSeq

12
UniProt

7
CCDS

CCDS26862.1, CCDS88589.1

Ensembl

ENSMUSG00000039197 (Evidence)
NCBI Gene

11534

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039197	Ensembl Gene Model \| MGI Sequence Detail	395996	C57BL/6J	± kb
transcript	ENSMUST00000045376	Ensembl \| MGI Sequence Detail	1782	Not Applicable
polypeptide	ENSMUSP00000047665	Ensembl \| MGI Sequence Detail	361	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003780 adenosine kinase

(term hierarchy)
PDB

5KB5, 5KB6
EC

2.7.1.-, 2.7.1.20
InterPro Domains

IPR001805 Adenosine kinase

IPR011611 Carbohydrate kinase PfkB

IPR002173 Carbohydrate/purine kinase, PfkB, conserved site

IPR029056 Ribokinase-like
GlyGen

P55264 1 site, 1 O-linked glycan (1 site)

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All nucleic 169

cDNA 168

Primer pair 1

Antibodies 1

Microarray probesets 10

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MGD-MRK-1129, MGI:1916830, MGI:1923219, MGI:2145606, MGI:2145711

Summaries

All 109

Developmental Gene Expression 8

Diseases 1

Gene Ontology 25

Phenotypes 40
Earliest

J:308489 Wong PC, et al., Purine ribonucleotide biosynthesis, interconversion and catabolism in mouse brain in vitro. Biochem J. 1972 Oct;129(5):1085-94
Latest

J:388776 Liu R, et al., Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1. J Exp Med. 2026 Jan 5;223(1)

TSS for Adk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124410	Chr14:21101902-21101907 (+)	-737 bp
Tssr124411	Chr14:21102645-21102657 (+)	9 bp
Tssr124412	Chr14:21102662-21102701 (+)	40 bp
Tssr124413	Chr14:21126204-21126215 (+)	23,568 bp
Tssr124414	Chr14:21126237-21126290 (+)	23,622 bp
Tssr124415	Chr14:21127089-21127093 (+)	24,449 bp
Tssr124416	Chr14:21154486-21154489 (+)	51,846 bp
Tssr124417	Chr14:21161316-21161324 (+)	58,678 bp
Tssr124418	Chr14:21229724-21229727 (+)	127,084 bp
Tssr124419	Chr14:21232731-21232742 (+)	130,095 bp
Tssr124420	Chr14:21244547-21244553 (+)	141,908 bp
Tssr124421	Chr14:21244642-21244654 (+)	142,006 bp
Tssr124422	Chr14:21293540-21293550 (+)	190,903 bp
Tssr124423	Chr14:21300674-21300691 (+)	198,041 bp
Tssr4338	Chr14:21326954-21326955 (+)	224,313 bp
Tssr124426	Chr14:21330811-21330817 (+)	228,172 bp
Tssr124427	Chr14:21357663-21357666 (+)	255,023 bp
Tssr124428	Chr14:21363536-21363545 (+)	260,899 bp
Tssr124429	Chr14:21395641-21395660 (+)	293,009 bp
Tssr124430	Chr14:21406385-21406389 (+)	303,745 bp
Tssr124431	Chr14:21476751-21476752 (+)	374,110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24