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Gene Expression Data
Assay Details
Assay
Reference: J:253351 Hanley O, et al., Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8207401
Gene symbol: Hoxc8
Gene name: homeobox C8
Antibody: Anti-Hoxc8
Results
Specimen 1I Control rostral brachial: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Ambiguous 1I Hoxc8 Control rostral brachial
Specimen 1I PbxMNdelta rostral brachial: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Ambiguous 1I Hoxc8 PbxMNdelta rostral brachial Hoxc8 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen 1I Control caudal brachial: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Present 1I Hoxc8 Control caudal brachial The expression domain was restricted to the caudal brachial region.
Specimen 1I PbxMNdelta caudal brachial: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Present 1I Hoxc8 PbxMNdelta caudal brachial Hoxc8 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen S1D: embryonic day 11.5 (more )
Note: Double labeled: green - Hoxc8; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present Regionally restricted S1D Pbx3 Hoxc8 Immunopositive lateral motor column neurons in the caudal brachial region colocalized with Pbx3 in a subset of neurons.
Specimen S1I Control rostral: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Double labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Ambiguous Regionally restricted S1I Control rostral Hoxc8 marked the caudal brachial region; rostral expression was not specified.
Specimen S1I PbxMNdelta rostral: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Double labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Ambiguous Regionally restricted S1I PbxMNdelta rostral Hoxc8 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen S1I Control middle: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Double labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Weak Regionally restricted S1I Control
Specimen S1I PbxMNdelta middle: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Double labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Weak Regionally restricted S1I PbxMNdelta Hoxc8 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen S1I Control caudal: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Double labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Present Regionally restricted S1I Control caudal Hoxc8 marked the caudal brachial region.
Specimen S1I PbxMNdelta caudal: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Double labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Present Regionally restricted S1I PbxMNdelta caudal Hoxc8 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen S1K Control right: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Triple labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399); blue - Isl1 (assay MGI:8206395) and Isl2 (assay MGI:8207778).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Present Regionally restricted S1K Control Hoxa5 Isl1/2 Hoxc8 Hoxc8 marked the caudal brachial region.
Specimen S1K PbxMNdelta right: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Triple labeled: green - Hoxc8; red - Hoxa5 (assay MGI:8207399); blue - Isl1 (assay MGI:8206395) and Isl2 (assay MGI:8207778).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Present S1K PbxMNdelta Hoxa5 Isl1/2 Hoxc8 Hoxc8 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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