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Gene Expression Data
Assay Details
Assay
Reference: J:178173 Mastracci TL, et al., Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8161241
Gene symbol: Ghrl
Gene name: ghrelin
Antibody: anti-ghrelin
Detection system: Secondary antibody coupled to Cy2
Results
Specimen 1C: embryonic day 13.5 (more )
Note: Double labeled: green - Ghrl; red - Arx (assay MGI:8161239).
Structure Cell Type Level Pattern Image Note
TS21: pancreas pancreatic epsilon cell Present 1C Coexpression with Arx was seen.
Specimen 1E: embryonic day 13.5; Nkx2-2tm1Jlr/Nkx2-2tm1Jlr (more )
Note: Double labeled: green - Ghrl; red - Arx (assay MGI:8161239).
Structure Cell Type Level Pattern Image Note
TS21: pancreas pancreatic epsilon cell Present 1E Increased number of positive cells in the mutant.
Specimen 2K/N: embryonic day 15.5 (more )
Note: Triple labeled: green - Ghrl; red - Arx (assay MGI:8161239); blue - Gcg (assay MGI:8161643).
Structure Cell Type Level Pattern Image Note
TS23: pancreas pancreatic epsilon cell Present 2K , 2N
Specimen 4E: postnatal day 0 (more )
Note: Double labeled: green - Ghrl; red - Gcg (assay MGI:8161242).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 4E
Specimen 4F: postnatal day 0; Arxtm1Gldn/?, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: green - Ghrl; red - Gcg (assay MGI:8161242).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 4F Similar as in the wild-type.
Specimen 4G: postnatal day 0; Nkx2-2tm1Jlr/Nkx2-2tm1Jlr (more )
Note: Double labeled: green - Ghrl; red - Gcg (assay MGI:8161242).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 4G Increased number of positive cells, compared with the wild-type.
Specimen 4H: postnatal day 0; Arxtm1Gldn/?, Nkx2-2tm1Jlr/Nkx2-2tm1Jlr, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: green - Ghrl; red - Gcg (assay MGI:8161242).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 4H Increased number of positive cells, compared with the wild-type.
Specimen 6E: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 6E
Specimen 6F: postnatal day 0; Arxtm1Gldn/?, Tg(Neurog3-cre)C1Able/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male.
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 6F Similar as in the wild-type.
Specimen 6G: postnatal day 0; Nkx2-2tm1Jlr/Nkx2-2tm1Jlr (more )
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 6G Increased expression compared with the wild-type.
Specimen 6H: postnatal day 0; Arxtm1Gldn/?, Nkx2-2tm1Jlr/Nkx2-2tm1Jlr, Tg(Neurog3-cre)C1Able/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male.
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic epsilon cell Present 6H Increased expression compared with the wild-type, although reduced in the this double mutant compared with the single Nkx2-2 null.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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