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Gene Expression Data
Assay Details
Assay
Reference: J:198779 Nitzan E, et al., Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12709-14
Assay type: RNA in situ
MGI Accession ID: MGI:7779998
Gene symbol: Mitf
Gene name: melanogenesis associated transcription factor
Probe: Mitf cDNA
Probe preparation: Antisense RNA
Results
Specimen 4A/A': embryonic day 12.5; Foxd3+/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: purple - Mitf; red - Tubb3 (assay MGI:7780007).
Structure Cell Type Level Pattern Image Note
TS20: dermis melanocyte Present 4A , 4A'
TS20: epidermis melanocyte Present 4A , 4A'
Specimen 4B/B': embryonic day 12.5; Foxd3tm1Lby/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: purple - Mitf; red - Tubb3 (assay MGI:7780007).
Structure Cell Type Level Pattern Image Note
TS20: dermis melanocyte Present 4B' , 4B
TS20: epidermis melanocyte Present 4B' , 4B
TS20: spinal nerve Schwann cell precursor Present 4B' , 4B Positive cells were apparent along the mutant nerves in addition to their expected dermal/ectodermal distribution.
Specimen 4C/C': embryonic day 11.5; Foxd3+/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: purple - Mitf; red - Tubb3 (assay MGI:7780007).
Structure Cell Type Level Pattern Image Note
TS19: integumental system melanocyte Present Regionally restricted 4C , 4C' Positive melanocytes were observed in the neighboring hypaxial dermis and ectoderm.
Specimen 4D/D': embryonic day 11.5; Foxd3tm1Lby/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: purple - Mitf; red - Tubb3 (assay MGI:7780007).
Structure Cell Type Level Pattern Image Note
TS19: integumental system melanocyte Present Regionally restricted 4D , 4D' Positive melanocytes were observed in the neighboring hypaxial dermis and ectoderm.
TS19: accessory nerve Schwann cell precursor Present 4D , 4D' Positive cells were apparent along the mutant nerves in addition to their expected dermal/ectodermal distribution.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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