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Gene Expression Data
Assay Details
Assay
Reference: J:324832 Sun Y, et al., Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep. 2022 Mar 22;38(12):110542
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7493529
Gene symbol: Phox2b
Gene name: paired-like homeobox 2b
Antibody: anti-Phox2b (B-11; sc-376997)
Detection system: Secondary antibody
Results
Specimen S1C: embryonic day 9.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Multi-labeled: green - Phox2b; white - Neurod1 (assay MGI:7493524); red - Cre reporter; blue - Hoechst.
Structure Level Pattern Image Note
TS16: cranial ganglion Strong Regionally restricted S1E' , S1D' , S1D''' , S1C' , S1E''' , S1C''' Expression is seen in cells committed to be geniculate ganglion cells. It is not seen in cells committed to be cochleo-vestibular ganglion cells.
Specimen S4D: embryonic day 11.5; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(Tlx3-cre)PL56Gsat/0 (more )
Note: Conditional mutant. Multi-labeled: green - Phox2b; white - Sox2 (assay MGI:7493756); red - Cre reporter; blue - Hoechst.
Structure Level Pattern Image Note
TS20: facial ganglion Present Regionally restricted S4D'' , S4D''' , S4E
TS20: vestibular ganglion Absent S4D''' , S4D'' , S4E
TS20: hindbrain Present S4E , S4D''' , S4D''
Specimen S4G: embryonic day 11.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Multi-labeled: white - Phox2b; green - Onecut2 (assay MGI:7493870); red - Cre reporter; blue - Hoechst.
Structure Level Pattern Image Note
TS20: facial ganglion Present S4G''' , S4H''' , S4G'' , S4H''
TS20: hindbrain Present S4H''' , S4G''' , S4G'' , S4H''
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory