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Gene Expression Data
Assay Details
Assay
Reference: J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7491892
Gene symbol: Dcx
Gene name: doublecortin
Antibody: anti-DCX
Results
Specimen 3C RMSob Control: postnatal adult; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Note: Double labeled: red - Dcx; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted 3C RMS Control Expression in migrating neuroblasts in rostral migratory stream.
Specimen 3C GCL Control: postnatal adult; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Note: Double labeled: red - Dcx; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Present Regionally restricted 3C GCL Control Expression in radially oriented processes extending from through granule cell layer, interdigitating between neurons.
Specimen 3C RMSob coTshz1: postnatal adult; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant. Double labeled: red - Dcx; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS28: rostral migratory stream Strong 3C RMS coTshz1 Strong expression in neuroblasts in rostral migratory stream
Specimen 3C GCL coTshz1: postnatal adult; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant. Double labeled: red - Dcx; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Absent 3C GCL coTshz1 No expression in radially oriented process outside of rostral migratory stream.
Specimen 3D Control: postnatal adult; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted 3D Control inset , 3D Control Expression in migrating neuroblasts in rostral migratory stream.
TS28: main olfactory bulb granule cell layer Present Regionally restricted 3D Control inset , 3D Control Expression in cells dispersed throuhgout granule cell layer. Expression in radially oriented processes.
Specimen 3D coTshz1: postnatal adult; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: rostral migratory stream Present 3D coTshz1 inset , 3D coTshz1 Expression accumulated in rostral migratory stream.
TS28: main olfactory bulb granule cell layer Present Regionally restricted 3D coTshz1 , 3D coTshz1 inset Expression in processes with no clear orientation.
Specimen 4E Control: postnatal week 5; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Note: Triple labeled: blue - Dcx; green - Rbfox3 (assay MGI:7491890); red - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb Present 4E Control
Specimen 4E coTshz1: postnatal week 5; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant. Triple labeled: blue - Dcx; green - Rbfox3 (assay MGI:7491890); red - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb Present 4E coTshz1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory