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Gene Expression Data
Assay Details
Assay
Reference: J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7491890
Gene symbol: Rbfox3
Gene name: RNA binding protein, fox-1 homolog (C. elegans) 3
Antibody: anti-NeuN
Results
Specimen 1B: postnatal day 0.5 (more )
Note: Double labeled: red - Rbfox3; green - Tshz1 (assay MGI:7491889).
Structure Level Pattern Image Note
TS27: rostral migratory stream Absent 1B Stream , 1B
TS27: main olfactory bulb granule cell layer Present 1B GCL , 1B Expression in differentiated neurons.
Specimen 1D: postnatal day 60 (more )
Note: Double labeled: red - Rbfox3; green - Tshz1 (assay MGI:7491889).
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Present 1D GCL , 1D Expression in differentiated neurons.
TS28: rostral migratory stream Absent 1D , 1D RMS
TS28: main olfactory bulb glomerular layer Present 1D , 1D GL
Specimen 2D Control: postnatal day 0.5; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Note: Double labeled: red - Rbfox3; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS27: main olfactory bulb glomerular layer Present 2D Control inset , 2D Control
TS27: main olfactory bulb granule cell layer Present 2D Control inset , 2D Control
Specimen 2D coTshz1: postnatal day 0.5; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant. Double labeled: red - Rbfox3; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS27: main olfactory bulb granule cell layer Absent 2D coTshz1 , 2D coTshz1 inset Loss of expression in outer granule cell layer
TS27: main olfactory bulb glomerular layer Present 2D coTshz1 inset , 2D coTshz1 Expression in glomerular layer unchanged.
Specimen 2I control: postnatal day 21; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Note: Double labeled: red - Rbfox3; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS28: main olfactory bulb Present 2I Control
Specimen 2I coTshz1: postnatal day 21; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant. Double labeled: red - Rbfox3; green - Tshz1 reporter (assay MGI:7491839).
Structure Level Pattern Image Note
TS28: main olfactory bulb Present 2I coTshz1
Specimen 4E control: postnatal week 5; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Note: Triple labeled: green - Rbfox3; blue - Dcx (assay MGI:7491892); red - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Present 4E Control
Specimen 4E coTshz1: postnatal week 5; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant. Triple labeled: green - Rbfox3; blue - Dcx (assay MGI:7491892); red - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Weak Regionally restricted 4E coTshz1 Decrease in cells differentiating into granule cell neurons.
Specimen S4A control: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Note: Double labeled: green - Rbfox3; red - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Present S4A control (merge) , S4A control NeuN
Specimen S4A coTshz1: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant. Double labeled: green - Rbfox3; red - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Weak Regionally restricted S4A coTshz1 NeuN , S4A coTshz1 (merge) Decrease in cells differentiating into granule cell neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
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