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Gene Expression Data
Assay Details
Assay
Reference: J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7448888
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Results
Specimen S4A Ctrl: embryonic day 10.5 (more )
Note: Double labeled: green - Mki67; red - Tnnt2 (assay MGI:7448838).
Structure Cell Type Level Pattern Image Note
TS17: cardiac muscle tissue cardiac muscle cell Present Regionally restricted S4A top Co-expression of Mki67 and Tnnt2 was detected in proliferating cardiomyocytes.
Specimen S4A KO: embryonic day 10.5; Znhit1tm1.1Nju/Znhit1tm1.1Nju, Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 (more )
Note: Conditional mutant. Double labeled: green - Mki67; red - Tnnt2 (assay MGI:7448838).
Structure Cell Type Level Pattern Image Note
TS17: cardiac muscle tissue cardiac muscle cell Present Regionally restricted S4A bottom Quantification of proliferating cardiomyocytes was not significantly different in the mutant compared to control at E10.5.
Specimen S4B Ctrl E11.5: embryonic day 11.5 (more )
Note: Double labeled: green - Mki67; red - Tnnt2 (assay MGI:7448838).
Structure Cell Type Level Pattern Image Note
TS19: cardiac muscle tissue cardiac muscle cell Present Regionally restricted S4B Ctrl E11.5 Co-expression of Mki67 and Tnnt2 was detected in proliferating cardiomyocytes.
Specimen S4B KO E11.5: embryonic day 11.5; Znhit1tm1.1Nju/Znhit1tm1.1Nju, Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 (more )
Note: Conditional mutant. Double labeled: green - Mki67; red - Tnnt2 (assay MGI:7448838).
Structure Cell Type Level Pattern Image Note
TS19: cardiac muscle tissue cardiac muscle cell Present Regionally restricted S4B KO E11.5 Quantification of proliferating cardiomyocytes was not significantly different in the mutant compared to control at E11.5.
Specimen S4B Ctrl E12.5: embryonic day 12.5 (more )
Note: Double labeled: green - Mki67; red - Tnnt2 (assay MGI:7448838).
Structure Cell Type Level Pattern Image Note
TS20: cardiac muscle tissue cardiac muscle cell Present Regionally restricted S4B Ctrl E12.5 Co-expression of Mki67 and Tnnt2 was detected in proliferating cardiomyocytes.
Specimen S4B KO E12.5: embryonic day 12.5; Znhit1tm1.1Nju/Znhit1tm1.1Nju, Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 (more )
Note: Conditional mutant. Double labeled: green - Mki67; red - Tnnt2 (assay MGI:7448838).
Structure Cell Type Level Pattern Image Note
TS20: cardiac muscle tissue cardiac muscle cell Present Regionally restricted S4B KO E12.5 Double labeled cells indicated decreased cardiomyocyte proliferation after E12.5.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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