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Gene Expression Data
Assay Details
Assay
Reference: J:284490 Varum S, et al., Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7332926
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2C Control: embryonic day 11.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre.
Structure Level Pattern Image Note
TS19: branchial arch Ambiguous 2C Control
Specimen 2C Yy1 cko: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: branchial arch Present 2C Yy1 cko Cell death increased at E11.5.
Specimen 2H Control: embryonic day 11.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: red - Casp3; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS19: dorsal root ganglion Trace 2H Control
Specimen 2H Yy1 cko: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present 2H Yy1 cko Cell death increased at E11.5.
Specimen 2I Control: embryonic day 13.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: red - Casp3; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS21: dorsal root ganglion Trace 2I Control
Specimen 2I Yy1 cko: embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present 2I Yy1 cko Reduced apoptosis at E13.5.`
Specimen S4B Control: embryonic day 9.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: red - Casp3; green - Yy1 (assay MGI:7332911).
Structure Level Pattern Image Note
TS15: branchial arch Trace S4B Control
Specimen S4B Yy1 cko: embryonic day 9.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Yy1 (assay MGI:7332911).
Structure Level Pattern Image Note
TS15: branchial arch Trace S4B Yy1 cko Apoptosis not yet evident.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory