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Gene Expression Data
Assay Details
Assay
Reference: J:310860 Liu S, et al., The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns. Neural Plast. 2018;2018:7513258
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7287430
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 1A: embryonic day 9.5 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Level Pattern Image Note
TS15: otocyst epithelium Present Widespread 1A3 , 1A2 Expressed in all sensory regions, with higher expression in the dorsolateral area.
Specimen 1B: embryonic day 11.5 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Level Pattern Image Note
TS19: saccule epithelium Present 1B2 , 1B3
TS19: utricle epithelium Present 1B2 , 1B3
TS19: otocyst epithelium Present Regionally restricted 1B2 , 1B3 Expressed in sensory primordia of the prosensory domain of the cochlea.
Specimen 1C: embryonic day 12.5 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Level Pattern Image Note
TS20: cochlear duct epithelium Present Regionally restricted 1C3 , 1C2 Expressed in the medial half of the duct that appeared to correspond with the prosensory domain, specifically the population of cells that would give rise to the organ of Corti.
Specimen 1D: embryonic day 13.5 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Level Pattern Image Note
TS21: cochlear duct Present Regionally restricted 1D2 , 1D3 Expressed within the basal region of the cochlear duct, which is correlated with the position of the developing organ of Corti and Kolliker's organ.
TS21: cochlear duct epithelium Present Regionally restricted 1D2 , 1D3 Expression was gradually restricted to the prosensory domain, primarily in the medial half of the cochlear duct at the apex.
Specimen 2A2/A3: embryonic day 15.5 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2A3 , 2A2 Expressed in the medial half of the cochlear duct at the apex as well as within the basal region of the cochlear duct that is correlated with the position of the developing organ of Corti and Kolliker's organ.
Specimen 2A5: embryonic day 15.5 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2A5 Expressed in the medial half of the cochlear duct at the apex as well as within the basal region of the cochlear duct that is correlated with the position of the developing organ of Corti and Kolliker's organ.
Specimen 2B2/B3: embryonic day 16.5 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Cell Type Level Pattern Image Note
TS24: cochlear duct epithelium cochlea auditory hair cell Present 2B2 , 2B3
TS24: cochlear duct epithelium supporting cell of cochlea Present 2B2 , 2B3
TS24: organ of Corti cochlea auditory hair cell Present 2B3 , 2B2
TS24: organ of Corti supporting cell of cochlea Present 2B3 , 2B2
Specimen 2B5: embryonic day 16.5 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Cell Type Level Pattern Image Note
TS24: cochlear duct epithelium cochlea auditory hair cell Present 2B5
TS24: cochlear duct epithelium supporting cell of cochlea Present 2B5
TS24: organ of Corti cochlea auditory hair cell Present 2B5
TS24: organ of Corti supporting cell of cochlea Present 2B5
Specimen 2C2/C3: embryonic day 18.5 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti cochlea auditory hair cell Present 2C2 , 2C3
Specimen 2C5: embryonic day 18.5 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti cochlea auditory hair cell Present 2C5
Specimen 3B2: embryonic day 15.5 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Level Pattern Image Note
TS23: saccule epithelium Present 3B2
Specimen 3C2: embryonic day 15.5 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Level Pattern Image Note
TS23: utricle epithelium Present 3C2
Specimen 3C3: embryonic day 15.5 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Level Pattern Image Note
TS23: semicircular canal epithelium Present 3C3
Specimen 4C2/C3: embryonic day 18.5 (more )
Note: Double labeled: red - Sox2; green - Prox1 (assay MGI:7287438).
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium supporting cell of cochlea Present 4C2 , 4C3 Expressed in all of the supporting cells and in a group of cells within Kolliker's organ.
Specimen 5C: embryonic day 18.5 (more )
Note: Double labeled: red - Sox2; green - Prox1 (assay MGI:7287438).
Structure Level Pattern Image Note
TS26: saccule epithelium Present 5C2 , 5C3
TS26: utricle epithelium Present 5C2 , 5C3
Specimen 6A2/A3: postnatal day 0 (more )
Note: Double labeled: red - Sox2; green - Pax2 (assay MGI:7287428).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Deiter's cell Present Regionally restricted 6A3 , 6A2 Expressed in the basal region of the cochlea and a group of cells within Kolliker's organ.
TS27: cochlea epithelium external pillar cell of cochlea Present Regionally restricted 6A3 , 6A2 Expressed in the basal region of the cochlea and a group of cells within Kolliker's organ.
TS27: cochlea epithelium Hensen cell Present Regionally restricted 6A3 , 6A2 Expressed in the basal region of the cochlea and a group of cells within Kolliker's organ.
TS27: cochlea epithelium inner phalangeal cell Present Regionally restricted 6A3 , 6A2 Expressed in the basal region of the cochlea and a group of cells within Kolliker's organ.
TS27: cochlea epithelium internal pillar cell of cochlea Present Regionally restricted 6A3 , 6A2 Expressed in the basal region of the cochlea and a group of cells within Kolliker's organ.
Specimen 6B2: postnatal day 7 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium supporting cell of cochlea Present 6B2
Specimen 6C4: postnatal day 7 (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7287437).
Structure Cell Type Level Pattern Image Note
TS28: crista ampullaris supporting cell of vestibular epithelium Present 6C4
TS28: crista ampullaris vestibular hair cell Present 6C4
Specimen 7A2/A3: postnatal day 0 (more )
Note: Double labeled: red - Sox2; green - Prox1 (assay MGI:7287438).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium supporting cell of cochlea Present 7A2 , 7A3
Specimen 7B2/B3: postnatal day 7 (more )
Note: Double labeled: red - Sox2; green - Prox1 (assay MGI:7287438).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium supporting cell of cochlea Present 7B2 , 7B3
Specimen 7C2/C3: postnatal day 7 (more )
Note: Double labeled: red - Sox2; green - Prox1 (assay MGI:7287438).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium supporting cell of cochlea Present 7C2 , 7C3
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory