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Gene Expression Data
Assay Details
Assay
Reference: J:310860 Liu S, et al., The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns. Neural Plast. 2018;2018:7513258
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7287428
Gene symbol: Pax2
Gene name: paired box 2
Antibody: anti-Pax2
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A: embryonic day 9.5 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Level Pattern Image Note
TS15: otocyst epithelium Present Widespread 1A3 , 1A1 Expressed throughout the epithelium, but it was more concentrated in the centro-medial area next to the neural tube.
Specimen 1B: embryonic day 11.5 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Level Pattern Image Note
TS19: saccule epithelium Present 1B3 , 1B1
TS19: otocyst epithelium Present Regionally restricted 1B1 , 1B3 Expressed in the sensory regions of the cochlea, mostly restricted to the posterior region.
Specimen 1C: embryonic day 12.5 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Level Pattern Image Note
TS20: cochlear duct epithelium Present Regionally restricted 1C1 , 1C3 Mainly expressed in both sides of Reissner's membrane.
TS20: saccule epithelium Present 1C1 , 1C3 Gradually weakened in the prosensory domain.
Specimen 1D: embryonic day 13.5 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Level Pattern Image Note
TS21: cochlea Present Regionally restricted 1D1 , 1D3 Mainly located in the nonsensory domains.
TS21: inner ear vestibular component Present Regionally restricted 1D1 , 1D3 Mainly located in the nonsensory domains.
Specimen 2A1/A3: embryonic day 15.5 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2A1 , 2A3 Expressed in the Reissner's membrane and the stria vascularis. Not coexpressed with Myo7a.
TS23: cochlear duct epithelium cochlea auditory hair cell Absent 2A1 , 2A3
Specimen 2A4: embryonic day 15.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2A4 Expressed in the Reissner's membrane and the stria vascularis. Not coexpressed with Myo7a.
TS23: cochlear duct epithelium cochlea auditory hair cell Absent 2A4
Specimen 2B1/B3: embryonic day 16.5 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS24: cochlear duct epithelium Present 2B3 , 2B1
TS24: organ of Corti cochlea auditory hair cell Present 2B1 , 2B3
Specimen 2B4: embryonic day 16.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS24: cochlear duct epithelium Present 2B4
TS24: organ of Corti cochlea auditory hair cell Present 2B4
Specimen 2C1/C3: embryonic day 18.5 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS26: cochlear duct epithelium Present 2C1 , 2C3
TS26: organ of Corti cochlea auditory hair cell Present 2C1 , 2C3
Specimen 2C4: embryonic day 18.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS26: cochlear duct epithelium Present 2C4
TS26: organ of Corti cochlea auditory hair cell Present 2C4
Specimen 3A1: embryonic day 15.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Level Pattern Image Note
TS23: endolymphatic duct epithelium Present 3A1
TS23: saccule epithelium Present 3A1
Specimen 3A2: embryonic day 15.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS23: semicircular canal epithelium vestibular hair cell Present Regionally restricted 3A2 Only in the hair cells of the crista ampullaris.
TS23: saccule epithelium Present 3A2
TS23: utricle epithelium Present 3A2
Specimen 3A3: embryonic day 15.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS23: semicircular canal epithelium vestibular hair cell Present Regionally restricted 3A3 Only in the hair cells of the crista ampullaris.
Specimen 3B1: embryonic day 16.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS24: saccule epithelium vestibular hair cell Present 3B1 Expressed in immature hair cells and supporting cells.
TS24: macula of utricle vestibular hair cell Present 3B1
Specimen 3B3: embryonic day 16.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS24: semicircular canal epithelium vestibular hair cell Present 3B3 Only in the hair cells of the crista ampullaris.
Specimen 3C1: embryonic day 18.5 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS26: saccule epithelium vestibular hair cell Present 3C1
Specimen 6A1/A3: postnatal day 0 (more )
Note: Double labeled: green - Pax2; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium cochlear inner hair cell Present Regionally restricted 6A1 , 6A3 Weaker expression in the basal region of the cochlea.
Specimen 6A4: postnatal day 0 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium cochlear inner hair cell Present 6A4 Weaker expression in the basal region of the cochlea.
Specimen 6B1: postnatal day 7 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Absent 6B1
TS28: organ of Corti cochlear outer hair cell Absent 6B1
Specimen 6C1/C2: postnatal day 7 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS28: saccule epithelium vestibular hair cell Present 6C2 , 6C1
TS28: utricle epithelium vestibular hair cell Present 6C2 , 6C1
Specimen 6C3: postnatal day 7 (more )
Note: Double labeled: green - Pax2; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS28: crista ampullaris vestibular hair cell Present 6C3
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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