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Gene Expression Data
Assay Details
Assay
Reference: J:310860 Liu S, et al., The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns. Neural Plast. 2018;2018:7513258
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7287438
Gene symbol: Prox1
Gene name: prospero homeobox 1
Antibody: anti-Prox1
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4A: embryonic day 15.5 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS23: cochlea epithelium cochlear outer hair cell Present Regionally restricted 4A3 , 4A1 Expressed in the precursor cells in the most basal region of the developing cochlea, including in the future outer hair cells, Dieter's cells, and pillar cells.
TS23: cochlea epithelium Deiter's cell Present Regionally restricted 4A3 , 4A1 Expressed in the precursor cells in the most basal region of the developing cochlea, including in the future outer hair cells, Dieter's cells, and pillar cells.
TS23: cochlea epithelium pillar cell Present Regionally restricted 4A3 , 4A1 Expressed in the precursor cells in the most basal region of the developing cochlea, including in the future outer hair cells, Dieter's cells, and pillar cells.

Specimen 4B: embryonic day 16.5 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS24: cochlea epithelium Deiter's cell Present Regionally restricted 4B1 , 4B3 Expressed in the precursor cells in the basal region of the developing cochlea, including in the future Dieter's cells, and pillar cells.
TS24: cochlea epithelium pillar cell Present Regionally restricted 4B1 , 4B3 Expressed in the precursor cells in the basal region of the developing cochlea, including in the future Dieter's cells, and pillar cells.

Specimen 4C1/C3: embryonic day 18.5 (more )
Note: Double labeled: green - Prox1; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium supporting cell of cochlea Strong 4C3 , 4C1 The supporting cells underlying the hair cells expressed high levels, but supporting cells underlying the inner hair cells had no expression.
TS26: cochlea epithelium border cell of cochlea Absent 4C1 , 4C3
TS26: cochlea epithelium Hensen cell Absent 4C1 , 4C3
TS26: cochlea epithelium inner phalangeal cell Absent 4C1 , 4C3

Specimen 4C4: embryonic day 18.5 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium supporting cell of cochlea Strong 4C4 The supporting cells underlying the hair cells expressed high levels, but supporting cells underlying the inner hair cells had no expression.
TS26: cochlea epithelium border cell of cochlea Absent 4C4
TS26: cochlea epithelium Hensen cell Absent 4C4
TS26: cochlea epithelium inner phalangeal cell Absent 4C4

Specimen 5A1/A3: embryonic day 15.5 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Level Pattern Image Note
TS23: semicircular canal epithelium Present Regionally restricted 5A1 , 5A3 Expressed in the crista ampullaris.
TS23: utricle epithelium Present 5A3 , 5A1

Specimen 5B1/B3: embryonic day 16.5 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Level Pattern Image Note
TS24: semicircular canal epithelium Present Regionally restricted 5B1 , 5B3 Expressed in the crista ampullaris.
TS24: utricle epithelium Present 5B1 , 5B3

Specimen 5C1/C3: embryonic day 18.5 (more )
Note: Double labeled: green - Prox1; red - Sox2 (assay MGI:7287430).
Structure Level Pattern Image Note
TS26: saccule epithelium Present 5C1 , 5C3
TS26: utricle epithelium Absent 5C1 , 5C3

Specimen 7A1/A3: postnatal day 0 (more )
Note: Double labeled: green - Prox1; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Deiter's cell Present 7A3 , 7A1
TS27: cochlea epithelium pillar cell Present 7A3 , 7A1

Specimen 7A4: postnatal day 0 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Deiter's cell Present 7A4
TS27: cochlea epithelium pillar cell Present 7A4

Specimen 7B1/B3: postnatal day 7 (more )
Note: Double labeled: green - Prox1; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Deiter's cell Present 7B1 , 7B3 Reduced expression.
TS28: cochlea epithelium pillar cell Present 7B1 , 7B3 Reduced expression.

Specimen 7B4: postnatal day 7 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Deiter's cell Present 7B4 Reduced expression.
TS28: cochlea epithelium pillar cell Present 7B4 Reduced expression.

Specimen 7C1/C3: postnatal day 7 (more )
Note: Double labeled: green - Prox1; red - Sox2 (assay MGI:7287430).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Deiter's cell Weak 7C3 , 7C1 Reduced expression.
TS28: cochlea epithelium pillar cell Weak 7C3 , 7C1 Reduced expression.

Specimen 7C4: postnatal day 7 (more )
Note: Double labeled: green - Prox1; red - Myo7a (assay MGI:7287435).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Deiter's cell Weak 7C4 Reduced expression. Even more weakly expressed in the basal region.
TS28: cochlea epithelium pillar cell Weak 7C4 Reduced expression. Even more weakly expressed in the basal region.

Specimen not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: vestibular component epithelium Weak
TS21: cochlea Absent


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory