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Gene Expression Data
Assay Details
Assay
Reference: J:251629 Waclaw RR, et al., Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon. Mol Cell Neurosci. 2017 Apr;80:44-51
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6508064
Gene symbol: Foxo1
Gene name: forkhead box O1
Antibody: anti-Foxo1
Detection system: Secondary antibody
Results
Specimen 1B: embryonic day 15.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Isl1tm1(cre)Tmj/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: corpus striatum Present 1B , 1C Expression is stronger in the dorsolateral region.
Specimen 1E: embryonic day 18.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Isl1tm1(cre)Tmj/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: corpus striatum Present 1E , 1F Expression is stronger in the dorsolateral region.
Specimen 1H: embryonic day 18.5 (more )
Note: Double labeled: green - Foxo1; red - Ebf1 (assay MGI:6508074).
Structure Level Pattern Image Note
TS26: corpus striatum Present 1H , 1I Expression is stronger in the dorsolateral region.
Specimen 1J: embryonic day 18.5 (more )
Note: Double labeled: red - Foxo1; green - Foxp1 (assay MGI:6508079).
Structure Level Pattern Image Note
TS26: corpus striatum Present 1J Expression is stronger in the dorsolateral region.
Specimen 1K: embryonic day 18.5 (more )
Note: Double labeled: red - Foxo1; green - Foxp1 (assay MGI:6508079).
Structure Level Pattern Image Note
TS26: corpus striatum Present 1K Expression is in both the nucleus and cytoplasm.
Specimen 1L: embryonic day 18.5 (more )
Note: Double labeled: red - Foxo1; green - Nkx2-1 (assay MGI:6508080).
Structure Level Pattern Image Note
TS26: corpus striatum Present 1L Expression is in both the nucleus and cytoplasm.
Specimen 2A: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: corpus striatum Present Regionally restricted 2A Expression is in the cytoplasm and neuronal cell bodies and neuropil in direct and indirect pathway striatal projection neurons.
TS28: globus pallidus Present Regionally restricted 2A Expression is in striatal projection neuron fibers and terminals in the external and internal segment of the globus pallidus.
TS28: substantia nigra Present Regionally restricted 2A Expression is in striatal projection neuron fibers and terminals.
TS28: hippocampus Present 2A
Specimen 2B: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: corpus striatum Present Regionally restricted 2B Expression is in the cytoplasm and neuronal cell bodies and neuropil in direct and indirect pathway striatal projection neurons.
TS28: globus pallidus Present Regionally restricted 2B Expression is in striatal projection neuron fibers and terminals in the external and internal segment of the globus pallidus.
TS28: substantia nigra Present Regionally restricted 2B Expression is in striatal projection neuron fibers and terminals.
TS28: hippocampus Present 2B
Specimen 3E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: corpus striatum Present 3E
Specimen 3F: embryonic day 18.5; Isl1tm1.1Whk/Isl1tm1.1Whk, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: corpus striatum Present 3F Approximately 92% of Foxo1-positive cells co-expressed Ebf1.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/04/2024
MGI 6.13 		The Jackson Laboratory