About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:265020 Tang X, et al., EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. J Clin Invest. 2017 Dec 1;127(12):4314-4325
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6456988
Gene symbol: Sftpc
Gene name: surfactant associated protein C
Antibody: anti-Pro-SP-C (WRAB-9337)
Assay notes: Two proSP-C (Sftpc) antibodies were described; the one used in this assay was not detailed. Anti-proSP-C (MGI:6456917) may have been used in this assay.
Results
Specimen 3C: embryonic day 18.5 (more )
Note: Double labeled: green - proSP-C (Sftpc); red - mSP-C (Sftpc assay MGI:6456989).
Structure Level Pattern Image Note
TS26: lung Present 3C merge , 3C proSP-C
Specimen 3D: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Double labeled: green - proSP-C (Sftpc); red - mSP-C (Sftpc assay MGI:6456989).
Structure Level Pattern Image Note
TS26: lung alveolus Present Regionally restricted 3D proSP-C , 3D merge Expression accumulated in cytoplasm of alveolar type 2 (AT2) cells.
Specimen 3E: embryonic day 18.5 (more )
Note: Triple labeled: purple - proSP-C (Sftpc); green - proSP-B (Sftpb assay MGI:6456987); red - Lamp1 (assay MGI:6456990).
Structure Level Pattern Image Note
TS26: lung Present 3E
Specimen 3F: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Triple labeled: purple - proSP-C (Sftpc); green - proSP-B (Sftpb assay MGI:6456987); red - Lamp1 (assay MGI:6456990).
Structure Level Pattern Image Note
TS26: lung alveolus Present Regionally restricted 3F Expression colocalized with LAMP-1 in alveolar type 2 (AT2) cells, indicating retention of unprocessed precursors.
Specimen S2E: embryonic day 18.5 (more )
Note: Double labeled: red - proSP-C (Sftpc); green - Hopx (assay MGI:6456993).
Structure Level Pattern Image Note
TS26: lung Present S2E proSP-C , S2E merge
Specimen S2F: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Double labeled: red - proSP-C (Sftpc); green - Hopx (assay MGI:6456993).
Structure Level Pattern Image Note
TS26: lung Present S2F proSP-C , S2F merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory