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Gene Expression Data
Assay Details
Assay
Reference: J:175544 Dupuis LE, et al., Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease. Dev Biol. 2011 Sep 1;357(1):152-64
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6279801
Gene symbol: Bmp2
Gene name: bone morphogenetic protein 2
Antibody: anti-Bmp2
Results
Specimen 7A: embryonic day 15.5 (more )
Note: Triple labeled: green - Bmp2; blue - Acta1 (sarcomeric actin; assay MGI:6279797); red - propidium iodide.
Structure Level Pattern Image Note
TS23: pulmonary valve leaflet Present Widespread 7A Expression throughout developing cusps in pulmonary valves.
Specimen 7B: embryonic day 15.5; Adamts5tm1Dgen/Adamts5tm1Dgen (more )
Note: Triple labeled: green - Bmp2; blue - Acta1 (sarcomeric actin; assay MGI:6279797); red - propidium iodide.
Structure Level Pattern Image Note
TS23: pulmonary valve leaflet Present Widespread 7B Authors state both the domain and intensity of expression were not down-regulated and restricted in the extracellular matrix of valve cusps in mutant mice compared to wild type littermates.
Specimen 7C/C': embryonic day 17.5 (more )
Note: Double labeled: green - Bmp2; red - propidium iodide.
Structure Level Pattern Image Note
TS25: pulmonary valve leaflet Weak Regionally restricted 7C' , 7C Expression restricted to spongiosa layer and expression intensity reduced.
Specimen 7D/D': embryonic day 17.5; Adamts5tm1Dgen/Adamts5+ (more )
Note: Double labeled: green - Bmp2; red - propidium iodide.
Structure Level Pattern Image Note
TS25: pulmonary valve leaflet Strong Regionally restricted 7D , 7D' Authors report increased expression in pulmonary valve as well as lack of restriction.
Specimen 7E: postnatal day 1 (more )
Note: Double labeled: green - Bmp2; red - propidium iodide.
Structure Level Pattern Image Note
TS27: pulmonary valve Present 7E
Specimen 7F: postnatal day 1; Adamts5tm1Dgen/Adamts5tm1Dgen (more )
Note: Double labeled: green - Bmp2; red - propidium iodide.
Structure Level Pattern Image Note
TS27: pulmonary valve Strong 7F Increased amount as well as increased domain of expression compared to wild type littermates.
Specimen 9P: embryonic day 17.5 (more )
Note: Triple labeled: green - Bmp2; blue - Acta1 (sarcomeric actin; assay MGI:6279797); red - propidium iodide.
Structure Level Pattern Image Note
TS25: pulmonary valve leaflet Weak 9P
Specimen 9Q: embryonic day 17.5; Adamts5tm1Dgen/Adamts5tm1Dgen (more )
Note: Triple labeled: green - Bmp2; blue - Acta1 (sarcomeric actin; assay MGI:6279797); red - propidium iodide.
Structure Level Pattern Image Note
TS25: pulmonary valve leaflet Present 9Q
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
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