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Gene Expression Data
Assay Details
Assay
Reference: J:175242 Togashi H, et al., Nectins establish a checkerboard-like cellular pattern in the auditory epithelium. Science. 2011 Aug 26;333(6046):1144-7
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5641216
Gene symbol: Nectin3
Gene name: nectin cell adhesion molecule 3
Results
Specimen not shown: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: cochlea Present Regionally restricted Expression at junctions between auditory epithelia.

Specimen 1 Nectin-3: postnatal day 1 (more )
Note: Double labeled: green - Nectin3; red - Myo7a (assay MGI:5641213)
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 1_Nectin-3 , 1_Nectin-3/MyoVIIa Expression localized along heterotypic junctions between hair cells and supporting cells. Weak expression at junctions between supporting cells.

Specimen 3A WT: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present 3A Nectin-3

Specimen 3B Nectin-1 KO: postnatal day 1; Nectin1tm1Ytk/Nectin1tm1Ytk (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 3B Nectin-3 Expression upregulated at boundaries between supporting cells.

Specimen 3C Nectin-2 KO: postnatal day 1; Nectin2tm1Smu/Nectin2tm1Smu (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 3C Nectin-3 Authors report expression remained unchanged compared with wild type mice.

Specimen 3D Nectin-3 KO: postnatal day 1; Nectin3tm1Ytk/Nectin3tm1Ytk (more )
Structure Level Pattern Image Note
TS27: organ of Corti Absent 3D Nectin-3

Specimen S2C Nectin-3: embryonic day 16.0 (more )
Note: Double labeled: green - Nectin3; red - Myo7a (assay MGI:5641213)
Structure Level Pattern Image Note
TS24: organ of Corti Present Regionally restricted S2C Nectin-3 , S2C Nectin-3/MyoVIIa Expression at apical surface of auditory epithelium in middle turn of cochlea. Authors report expression at E16 similar to that at P1.

Specimen S3C Nectin-3: embryonic day 16.0 (more )
Note: Double labeled: green - Nectin3; red - Myo7a (assay MGI:5641213)
Structure Level Pattern Image Note
TS24: organ of Corti Present Regionally restricted S3C Nectin-3 , S3C Nectin-3/MyoVIIa Expression localized on apical side of lateral membranes of hair cells and supporting cells.

Specimen S3F Nectin-3: embryonic day 16.0 (more )
Note: Double labeled: green - Nectin3; red - Myo7a (assay MGI:5641213)
Structure Level Pattern Image Note
TS24: organ of Corti Present Regionally restricted S3F Nectin-3 , S3F Nectin-3/MyoVIIa Expression localized on apical side of lateral membranes of hair cells and supporting cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory