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Pvrig Gene Detail
Summary
  • Symbol
    Pvrig
  • Name
    poliovirus receptor related immunoglobulin domain containing
  • Synonyms
    Gm36869
Location &
Maps
more
  • Sequence Map
    Chr5:138340223-138341819 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5596028
 protein coding gene Chr5:138340193-138346953 (+)
129S1/SvImJ ENSMUSG00200043451
 protein coding gene Chr5:132212378-132213974 (+)
A/J ENSMUSG00195044537
 protein coding gene Chr5:131745682-131747278 (+)
AKR/J ENSMUSG00220046919
 protein coding gene Chr5:131091020-131092616 (+)
BALB/cJ ENSMUSG00180041714
 protein coding gene Chr5:131842265-131843861 (+)
C3H/HeJ ENSMUSG00175035663
 protein coding gene Chr5:133769730-133771326 (+)
C57BL/6NJ ENSMUSG00215047374
 protein coding gene Chr5:131783912-131785508 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005008722
 protein coding gene Chr5:131155808-131157404 (+)
CBA/J ENSMUSG00210022564
 protein coding gene Chr5:132587247-132588843 (+)
DBA/2J ENSMUSG00185052498
 protein coding gene Chr5:135602604-135604200 (+)
FVB/NJ ENSMUSG00205041702
 protein coding gene Chr5:131404158-131405754 (+)
JF1/MsJ ENSUMUG00000049479
 protein coding gene Chr5:138508190-138509786 (+)
LP/J ENSMUSG00230045619
 protein coding gene Chr5:139716051-139717647 (+)
NOD/ShiLtJ ENSMUSG00190045532
 protein coding gene Chr5:131541935-131543531 (+)
NZO/HlLtJ ENSMUSG00225020901
 protein coding gene Chr5:147269669-147271265 (+)
PWK/PhJ ENSLUMG00010014859
 protein coding gene Chr5:130231575-130233171 (+)
SPRET/EiJ ENSMSPG00010027582
 protein coding gene Chr5:133795144-133796676 (+)
WSB/EiJ ENSIUOG00005037856
 protein coding gene Chr5:134070550-134072145 (+)



Homology
more
  • Human Ortholog
    PVRIG, PVR related immunoglobulin domain containing
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PVRIG, PVR related immunoglobulin domain containing
  • Synonyms
    C7orf15, CD112R
  • Links
    NCBI Gene ID: 79037
    UniProt: Q6DKI7

  • Chr Location
    7q22.1; chr7:100218241-100221490 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased CD8+ effector T cell function and growth inhibition of implanted tumor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      25
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000109713 Ensembl Gene Model | MGI Sequence Detail 1597 C57BL/6J ±  kb
    transcript ENSMUST00000211088 Ensembl | MGI Sequence Detail 1080 Not Applicable  
    polypeptide ENSMUSP00000147735 Ensembl | MGI Sequence Detail 234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR034452 Transmembrane protein PVRIG
      IPR057367 Transmembrane protein PVRIG, immunoglobulin-like domain
    • GlyGen
      A0A1B0GS01 1 site
    References
    more
    • Summaries
      All 19
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:243463 Zhu Y, et al., Identification of CD112R as a novel checkpoint for human T cells. J Exp Med. 2016 Feb 08;213(2):167-76
    • Latest
      J:391236 Gao J, et al., Interferon-elicited lipoprotein metabolism in lung fibroblasts facilitates premetastatic niche formation. Nat Commun. 2026 Jul 1;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory