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Igkv12-46 Gene Detail
Summary
  • Symbol
    Igkv12-46
  • Name
    immunoglobulin kappa variable 12-46
  • Synonyms
    Gm16849
Location &
Maps
more
  • Sequence Map
    Chr6:69741507-69741976 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 31.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_4439773
 gene segment Chr6:69741507-69742006 (-)
129S1/SvImJ ENSMUSG00200012048
 gene segment Chr6:66647999-66648498 (-)
A/J ENSMUSG00195044627
 gene segment Chr6:66400922-66401421 (-)
AKR/J ENSMUSG00220046881
 gene segment Chr6:65465287-65465786 (-)
BALB/cJ ENSMUSG00180038609
 gene segment Chr6:66756795-66757294 (-)
C3H/HeJ ENSMUSG00175013548
 gene segment Chr6:110693020-110693519 (+)
C57BL/6NJ ENSMUSG00215043648
 gene segment Chr6:66731354-66731853 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005036414
 gene segment Chr6:66925423-66925922 (-)
CBA/J ENSMUSG00210040540
 gene segment Chr6:66554163-66554662 (-)
DBA/2J ENSMUSG00185043286
 gene segment Chr6:67119380-67119879 (-)
FVB/NJ ENSMUSG00205034077
 gene segment Chr6:66097838-66098337 (-)
JF1/MsJ ENSUMUG00000045507
 gene segment Chr6:66134768-66135267 (-)
LP/J ENSMUSG00230030396
 gene segment Chr6:68239684-68240183 (-)
NOD/ShiLtJ ENSMUSG00190043867
 gene segment Chr6:66075544-66076043 (-)
NZO/HlLtJ ENSMUSG00225021307
 gene segment Chr6:70213559-70214058 (-)
PWK/PhJ ENSLUMG00010021195
 gene segment Chr6:65555712-65556211 (-)
SPRET/EiJ ENSMSPG00010026748
 gene segment Chr6:67561744-67562246 (-)
WSB/EiJ ENSIUOG00005025394
 gene segment Chr6:67427689-67428188 (-)



Homology
more
  • Human Ortholog
    IGKV1-27, immunoglobulin kappa variable 1-27
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGKV1-27, immunoglobulin kappa variable 1-27
  • Synonyms
    A20, IGKV127
  • Links
    NCBI Gene ID: 28935
    UniProt: A0A075B6S5

  • Chr Location
    2p11.2; chr2:89213423-89213928 (-)  GRCh38
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
  • All Sequences
    24
  • RefSeq
    1
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 692245 NCBI Gene Model | MGI Sequence Detail 470 C57BL/6J ±  kb
polypeptide A0A140T8P6 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR003599 Immunoglobulin domain subtype
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR050150 Immunoglobulin Variable Light Chain
    IPR013106 Immunoglobulin V-set domain
References
more
  • Summaries
    All 8
    Gene Ontology 2
  • Earliest
    J:164271 Arnhold J, et al., Human myeloperoxidase in innate and acquired immunity. Arch Biochem Biophys. 2010 Aug 1;500(1):92-106
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory