About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3844072
Allelic
Composition		 Blnktm1Kplm/Blnktm1Kplm
Ightm4Cgn/Igh+
Igktm1Rsky/Igk+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Kplm mutation (0 available); any Blnk mutation (76 available)
Ightm4Cgn mutation (0 available); any Igh mutation (39 available)
Igktm1Rsky mutation (1 available); any Igk mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:120460 )
• innocuous transgenic BCR on Blnk null B cells leads to enhanced development of these B cells compared to Blnk homozygotes
• two populations are detected in the bone marrow consisting of IgMlo and IgMhi groups
• both populations appear to be immature B cells as they have low surface level expression of MHC-II and CD43, and high levels of CD24
• based on intensity of these surface markers, the IgMlo population is the less mature of the two
• in vitro maturation of bone marrow cells demonstrate delayed development of these IgM+ cells
• B cells in the periphery are primarily T1 stage B cells that have a short half-life
increased transitional stage B cell number ( J:120460 )
• B cells in the periphery are primarily T1 stage B cells
decreased B cell number ( J:120460 )
• B cell numbers are decreased 2- to 3- fold in the spleen
• the B cells present are primarily T1 stage B cells
increased pre-B cell number ( J:120460 )
• pre-B cell numbers are 2-3 fold higher in the bone marrow than in transgenic controls

hematopoietic system
abnormal B cell differentiation ( J:120460 )
• innocuous transgenic BCR on Blnk null B cells leads to enhanced development of these B cells compared to Blnk homozygotes
• two populations are detected in the bone marrow consisting of IgMlo and IgMhi groups
• both populations appear to be immature B cells as they have low surface level expression of MHC-II and CD43, and high levels of CD24
• based on intensity of these surface markers, the IgMlo population is the less mature of the two
• in vitro maturation of bone marrow cells demonstrate delayed development of these IgM+ cells
• B cells in the periphery are primarily T1 stage B cells that have a short half-life
increased transitional stage B cell number ( J:120460 )
• B cells in the periphery are primarily T1 stage B cells
decreased B cell number ( J:120460 )
• B cell numbers are decreased 2- to 3- fold in the spleen
• the B cells present are primarily T1 stage B cells
increased pre-B cell number ( J:120460 )
• pre-B cell numbers are 2-3 fold higher in the bone marrow than in transgenic controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory