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Prps1l3 Gene Detail
Summary
  • Symbol
    Prps1l3
  • Name
    phosphoribosyl pyrophosphate synthetase 1-like 3
  • Synonyms
    Gm5081
Location &
Maps
more
  • Sequence Map
    Chr12:57277198-57286668 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 24.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    374 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3779453
 protein coding gene Chr12:57277198-57288954 (+)
129S1/SvImJ ENSMUSG00200028901
 protein coding gene Chr12:49195776-49205246 (+)
A/J ENSMUSG00195001619
 protein coding gene Chr12:51756889-51766359 (+)
AKR/J ENSMUSG00220024958
 protein coding gene Chr12:49775294-49784764 (+)
BALB/cJ ENSMUSG00180007490
 protein coding gene Chr12:50777747-50787218 (+)
C3H/HeJ ENSMUSG00175015788
 protein coding gene Chr12:53818798-53828269 (+)
C57BL/6NJ ENSMUSG00215010317
 protein coding gene Chr12:50121596-50131066 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017770
 protein coding gene Chr12:52778438-52787762 (+)
CAST/EiJ ENSTCUG00005008782
 protein coding gene Chr12:50209464-50218835 (+)
CBA/J ENSMUSG00210009628
 protein coding gene Chr12:50293070-50302540 (+)
DBA/2J ENSMUSG00185000932
 protein coding gene Chr12:52238326-52247796 (+)
FVB/NJ ENSMUSG00205012994
 protein coding gene Chr12:50092528-50101999 (+)
JF1/MsJ ENSUMUG00000005315
 protein coding gene Chr12:56324343-56333699 (+)
LP/J ENSMUSG00230015183
 protein coding gene Chr12:59272613-59282083 (+)
NOD/ShiLtJ ENSMUSG00190015617
 protein coding gene Chr12:49286740-49296210 (+)
NZO/HlLtJ ENSMUSG00225040745
 protein coding gene Chr12:61403440-61412900 (+)
PWK/PhJ ENSLUMG00010016290
 protein coding gene Chr12:50389637-50391152 (+)
SPRET/EiJ ENSMSPG00010010876
 protein coding gene Chr12:51868314-51877549 (+)
WSB/EiJ ENSIUOG00005003385
 protein coding gene Chr12:50124892-50134363 (+)



Homology
more
  • Human Ortholog
    PRPS1, phosphoribosyl pyrophosphate synthetase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPS1, phosphoribosyl pyrophosphate synthetase 1
  • Synonyms
    ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRS-I, PRSI
  • Links
    NCBI Gene ID: 5631
    UniProt: P60891

  • Chr Location
    Xq22.3; chrX:107628428-107651993 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human PRPS1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Genomic Mutations
    1 involving Prps1l3
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    23 strains or lines available
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079104 Ensembl Gene Model | MGI Sequence Detail 9471 C57BL/6J ±  kb
transcript ENSMUST00000139049 Ensembl | MGI Sequence Detail 1720 Not Applicable  
polypeptide ENSMUSP00000133736 Ensembl | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
    2.7.6.1
  • InterPro Domains
    IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site
    IPR000836 Phosphoribosyltransferase domain
    IPR029057 Phosphoribosyltransferase-like
    IPR005946 Ribose-phosphate pyrophosphokinase
    IPR037515 Ribose-phosphate pyrophosphokinase, bacterial-type
    IPR029099 Ribose-phosphate pyrophosphokinase, N-terminal domain
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:382353 Kondoh S, et al., A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. J Hum Genet. 2002;47(3):136-9
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory