Tomt MGI Mouse Gene Detail - MGI:3769724 - transmembrane O-methyltransferase

Symbol

Tomt
Name

transmembrane O-methyltransferase
Synonyms

Comt2, F930017I19Rik

Feature Type

protein coding gene
IDs

MGI:3769724
NCBI Gene: 791260
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:101549010-101555572 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.68 cM
Mapping Data

1 experiment

SNPs within 2kb

170 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3769724	protein coding gene	Chr7:101547577-101555572 (-)
129S1/SvImJ	ENSMUSG00200045065	protein coding gene	Chr7:88389447-88397436 (-)
A/J	ENSMUSG00195054472	protein coding gene	Chr7:92895100-92903089 (-)
AKR/J	ENSMUSG00220047893	protein coding gene	Chr7:86311744-86319733 (-)
BALB/cJ	ENSMUSG00180031176	protein coding gene	Chr7:89568037-89576026 (-)
C3H/HeJ	ENSMUSG00175021223	protein coding gene	Chr7:90222732-90230730 (-)
C57BL/6NJ	ENSMUSG00215028959	protein coding gene	Chr7:89394646-89402635 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030070	protein coding gene	Chr7:104605068-104613277 (-)
CAST/EiJ	ENSTCUG00005052567	protein coding gene	Chr7:92804082-92812079 (-)
CBA/J	ENSMUSG00210024871	protein coding gene	Chr7:90076133-90084131 (-)
DBA/2J	ENSMUSG00185056161	protein coding gene	Chr7:94397913-94405911 (-)
FVB/NJ	ENSMUSG00205026734	protein coding gene	Chr7:90066236-90074225 (-)
JF1/MsJ	ENSUMUG00000042951	protein coding gene	Chr7:99298820-99306818 (-)
LP/J	ENSMUSG00230042922	protein coding gene	Chr7:100503567-100511556 (-)
NOD/ShiLtJ	ENSMUSG00190018959	protein coding gene	Chr7:90338944-90346933 (-)
NZO/HlLtJ	ENSMUSG00225049873	protein coding gene	Chr7:98736156-98744146 (-)
PWK/PhJ	ENSLUMG00010041824	protein coding gene	Chr7:88548669-88556665 (-)
SPRET/EiJ	ENSMSPG00010011163	protein coding gene	Chr7:89791894-89805511 (-)
WSB/EiJ	ENSIUOG00005008535	protein coding gene	Chr7:90660650-90668639 (-)

Human Ortholog

LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
Synonyms

CFAP111, DFNB63, LRRC51, LRRC51-TOMT
Links

HGNC:25033

NCBI Gene ID: 220074
Chr Location

11q13.4; chr11:72080331-72110782 (+) GRCh38

Human Ortholog

TOMT, transmembrane O-methyltransferase
Synonyms

COMT2
Links

HGNC:55527

NCBI Gene ID: 120356740
Chr Location

chr11:72103506-72110781 (+) GRCh38

MGI Vertebrate Homology

Tomt stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRTOMT, TOMT
Gene Tree

Tomt

Diseases

1 with Tomt mouse models; 1 with human LRTOMT associations

Human Disease

Mouse Models

autosomal recessive nonsyndromic deafness 63

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

29 phenotypes from 2 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Tomt
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a mutation of this gene exhibit marked hyperactivity, bidirectional circling and head-tossing. These behaviors are suppressed during sleep and nursing. Homozygous mutant males exhibit heightened male:male aggression.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase comt

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All Sequences

35
RefSeq

6
UniProt

1
CCDS

CCDS40044.1

Ensembl

ENSMUSG00000078630 (Evidence)
NCBI Gene

791260

			Length	Strain/Species	Flank
genomic	791260	NCBI Gene Model \| MGI Sequence Detail	6563	C57BL/6J	± kb
transcript	NM_001282088	RefSeq \| MGI Sequence Detail	1358	C57BL/6
polypeptide	A1Y9I9	UniProt \| EBI \| MGI Sequence Detail	258	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016933 transmembrane O-methyltransferase

(term hierarchy)
EC

2.1.1.6
InterPro Domains

IPR002935 Class I-like SAM-dependent O-methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 1

cDNA 1

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MGI:3707696

Summaries

All 38

Diseases 1

Gene Ontology 9

Phenotypes 20
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:257320 Erickson T, et al., Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife. 2017 May 23;6:e28474

TSS for Tomt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73884	Chr7:101554886-101554908 (-)	675 bp
Tssr73883	Chr7:101552990-101552993 (-)	2,580 bp
Tssr73882	Chr7:101552955-101552984 (-)	2,602 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24