About   Help   FAQ
Smpd5 Gene Detail
Summary
  • Symbol
    Smpd5
  • Name
    sphingomyelin phosphodiesterase 5
  • Synonyms
    1700010G02Rik, Gm10345
Location &
Maps
more
  • Sequence Map
    Chr15:76178548-76181096 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3709877
 protein coding gene Chr15:76178478-76181096 (+)
129S1/SvImJ ENSMUSG00200048948
 protein coding gene Chr15:73292744-73295292 (+)
A/J ENSMUSG00195049903
 protein coding gene Chr15:73267189-73269737 (+)
AKR/J ENSMUSG00220050190
 protein coding gene Chr15:73278212-73280760 (+)
BALB/cJ ENSMUSG00180052094
 protein coding gene Chr15:73092349-73094897 (+)
C3H/HeJ ENSMUSG00175052281
 protein coding gene Chr15:73455769-73458317 (+)
C57BL/6NJ ENSMUSG00215046740
 protein coding gene Chr15:73184570-73187118 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019917
 protein coding gene Chr15:70243391-70245843 (+)
CAST/EiJ ENSTCUG00005045154
 protein coding gene Chr15:72797627-72800175 (+)
CBA/J ENSMUSG00210034516
 protein coding gene Chr15:73231012-73233560 (+)
DBA/2J ENSMUSG00185046245
 protein coding gene Chr15:73208184-73210732 (+)
FVB/NJ ENSMUSG00205045941
 protein coding gene Chr15:72960441-72962989 (+)
JF1/MsJ ENSUMUG00000054967
 protein coding gene Chr15:72858126-72860674 (+)
LP/J ENSMUSG00230052370
 protein coding gene Chr15:76573683-76576231 (+)
NOD/ShiLtJ ENSMUSG00190045810
 protein coding gene Chr15:73213122-73215670 (+)
NZO/HlLtJ ENSMUSG00225051606
 protein coding gene Chr15:76878220-76880768 (+)
PWK/PhJ ENSLUMG00010049038
 protein coding gene Chr15:73143519-73146067 (+)
SPRET/EiJ ENSMSPG00010049729
 protein coding gene Chr15:74757535-74760080 (+)
WSB/EiJ ENSIUOG00005046708
 protein coding gene Chr15:73271050-73273598 (+)



Homology
more
  • Human Ortholog
    SMPD5, sphingomyelin phosphodiesterase 5 (pseudogene)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMPD5, sphingomyelin phosphodiesterase 5 (pseudogene)
  • Synonyms
    MA-nSMase, SMPD5P
  • Links
    NCBI Gene ID: 392275

  • Chr Location
    8q24.3; chr8:144049079-144051203 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    3
  • Gene trapped
    1
  • Radiation induced
    2
  • Genomic Mutations
    5 involving Smpd5
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071724 Ensembl Gene Model | MGI Sequence Detail 2549 C57BL/6J ±  kb
transcript ENSMUST00000163991 Ensembl | MGI Sequence Detail 1909 Not Applicable  
polypeptide ENSMUSP00000134687 Ensembl | MGI Sequence Detail 483 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.1.4.12
  • InterPro Domains
    IPR036691 Endonuclease/exonuclease/phosphatase superfamily
    IPR017766 Sphingomyelinase C/phospholipase C
    IPR038772 Sphingomyelinase C/Sphingomyelin phosphodiesterase 2-like
    IPR063161 Sphingomyelin phosphodiesterase 3/5, N-terminal transmembrane region
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 45
    Diseases 1
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory