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Rad21l Gene Detail
Summary
  • Symbol
    Rad21l
  • Name
    RAD21-like (S. pombe)
  • Synonyms
    Gm14160
Location &
Maps
more
  • Sequence Map
    Chr2:151487324-151510453 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
Strain
Comparison
more
  • SNPs within 2kb
    761 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3652039
 protein coding gene Chr2:151486286-151512542 (-)
129S1/SvImJ ENSMUSG00200025573
 protein coding gene Chr2:148392013-148415136 (-)
A/J ENSMUSG00195018989
 protein coding gene Chr2:148671843-148694984 (-)
AKR/J ENSMUSG00220042267
 protein coding gene Chr2:147995447-148018583 (-)
BALB/cJ ENSMUSG00180042398
 protein coding gene Chr2:148151582-148174713 (-)
C3H/HeJ ENSMUSG00175037810
 protein coding gene Chr2:148897869-148921004 (-)
C57BL/6NJ ENSMUSG00215017228
 protein coding gene Chr2:148330137-148353268 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024438
 protein coding gene Chr2:143543192-143566884 (-)
CAST/EiJ ENSTCUG00005038326
 protein coding gene Chr2:147264572-147287666 (-)
CBA/J ENSMUSG00210039043
 protein coding gene Chr2:148834365-148857502 (-)
DBA/2J ENSMUSG00185045259
 protein coding gene Chr2:148490164-148513307 (-)
FVB/NJ ENSMUSG00205030507
 protein coding gene Chr2:147591358-147614502 (-)
JF1/MsJ ENSUMUG00000044140
 protein coding gene Chr2:148170506-148192256 (-)
LP/J ENSMUSG00230033065
 protein coding gene Chr2:150144508-150167633 (-)
NOD/ShiLtJ ENSMUSG00190030145
 protein coding gene Chr2:148270199-148291945 (-)
NZO/HlLtJ ENSMUSG00225004772
 protein coding gene Chr2:158178332-158201467 (-)
PWK/PhJ ENSLUMG00010036888
 protein coding gene Chr2:148145906-148168048 (-)
SPRET/EiJ ENSMSPG00010025104
 protein coding gene Chr2:150864274-150887236 (-)
WSB/EiJ ENSIUOG00005042523
 protein coding gene Chr2:148006969-148030104 (-)



Homology
more
  • Human Ortholog
    RAD21L1, RAD21 cohesin complex component like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD21L1, RAD21 cohesin complex component like 1
  • Synonyms
    dJ545L17.2, RAD21L
  • Links
    NCBI Gene ID: 642636
    UniProt: Q9H4I0

  • Chr Location
    20p13; chr20:1226027-1296421 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility and reduced female fertility associated with abnormal meiosis and synaptonemal complex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    9
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074704 Ensembl Gene Model | MGI Sequence Detail 23130 C57BL/6J ±  kb
    transcript ENSMUST00000180195 Ensembl | MGI Sequence Detail 1659 Not Applicable  
    polypeptide ENSMUSP00000136918 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013668 double-strand-break repair protein rad21-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR049589 NXP-1, middle HEAT-repeat binding domain
      IPR039781 Rad21/Rec8-like protein
      IPR006909 Rad21/Rec8-like protein, C-terminal, eukaryotic
      IPR006910 Rad21/Rec8-like protein, N-terminal
      IPR023093 ScpA-like, C-terminal
      IPR036390 Winged helix DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 2
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    09/15/2026
    MGI 6.29     		The Jackson Laboratory