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Prr19 Gene Detail
Summary
  • Symbol
    Prr19
  • Name
    proline rich 19
  • Synonyms
    EG623131
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648539
    NCBI Gene: 623131
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25000836-25003557 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648539
 protein coding gene Chr7:25000784-25003565 (+)
129S1/SvImJ ENSMUSG00200040434
 protein coding gene Chr7:15004597-15007319 (+)
A/J ENSMUSG00195052139
 protein coding gene Chr7:17441791-17444512 (+)
AKR/J ENSMUSG00220051419
 protein coding gene Chr7:26946073-26948794 (-)
BALB/cJ ENSMUSG00180052547
 protein coding gene Chr7:15513755-15516476 (+)
C3H/HeJ ENSMUSG00175041947
 protein coding gene Chr7:16557867-16560588 (+)
C57BL/6NJ ENSMUSG00215054598
 protein coding gene Chr7:14917711-14920432 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029364
 protein coding gene Chr7:24569307-24572026 (+)
CAST/EiJ ENSTCUG00005049519
 protein coding gene Chr7:16612113-16614838 (+)
CBA/J ENSMUSG00210052644
 protein coding gene Chr7:15743594-15746315 (+)
DBA/2J ENSMUSG00185054079
 protein coding gene Chr7:18957352-18960073 (+)
FVB/NJ ENSMUSG00205050258
 protein coding gene Chr7:15754195-15756916 (+)
JF1/MsJ ENSUMUG00000017371
 protein coding gene Chr7:23253317-23256035 (+)
LP/J ENSMUSG00230052551
 protein coding gene Chr7:24230754-24233476 (+)
NOD/ShiLtJ ENSMUSG00190041757
 protein coding gene Chr7:15224493-15227215 (+)
NZO/HlLtJ ENSMUSG00225024871
 protein coding gene Chr7:22899351-22902072 (+)
PWK/PhJ ENSLUMG00010045859
 protein coding gene Chr7:15187107-15189842 (+)
SPRET/EiJ ENSMSPG00010040021
 protein coding gene Chr7:14851678-14854423 (+)
WSB/EiJ ENSIUOG00005049342
 protein coding gene Chr7:9719616-9722337 (+)



Homology
more
  • Human Ortholog
    PRR19, proline rich 19
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRR19, proline rich 19
  • Links
    NCBI Gene ID: 284338
    UniProt: A6NJB7

  • Chr Location
    19q13.2; chr19:42302098-42310814 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit female and male infertility due to defects in crossing over and double-strand break repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058741 Ensembl Gene Model | MGI Sequence Detail 2722 C57BL/6J ±  kb
    transcript ENSMUST00000080288 Ensembl | MGI Sequence Detail 1240 Not Applicable  
    polypeptide ENSMUSP00000104047 Ensembl | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 1
    References
    more
    • Summaries
      All 20
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:292293 Bondarieva A, et al., Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Nat Commun. 2020 Jun 18;11(1):3101
    • Latest
      J:361445 Ito M, et al., Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2412961121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory