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Defa43 Gene Detail
Summary
  • Symbol
    Defa43
  • Name
    defensin, alpha, 43
  • Synonyms
    Gm7861
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648003
    NCBI Gene: 665956
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:22083503-22084481 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648003
 protein coding gene Chr8:22083391-22084524 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033426
 protein coding gene Chr8:18854307-18855451 (-)
A/J MGP_AJ_G0033406
 protein coding gene Chr8:18884602-18887256 (-)
AKR/J MGP_AKRJ_G0033336
 protein coding gene Chr8:19252518-19253564 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0033117
 protein coding gene Chr8:19657303-19658978 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0030881
 protein coding gene Chr8:15504475-15505539 (-)
CAST/EiJ MGP_CASTEiJ_G0032444
 protein coding gene Chr8:19119733-19120867 (-)
CBA/J MGP_CBAJ_G0033094
 protein coding gene Chr8:21135145-21137859 (-)
DBA/2J MGP_DBA2J_G0033247
 protein coding gene Chr8:18861079-18862464 (-)
FVB/NJ MGP_FVBNJ_G0033192
 protein coding gene Chr8:18512439-18515823 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033234
 protein coding gene Chr8:20782211-20783341 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033939
 protein coding gene Chr8:18776286-18776670 (-)
PWK/PhJ MGP_PWKPhJ_G0032156
 protein coding gene Chr8:18272678-18273802 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032563
 protein coding gene Chr8:19525171-19526300 (-)



Homology
more
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Synonyms
    DEF1, DEFA2, HNP-1, HP-1, HP1, MRS
  • Links
    NCBI Gene ID: 1667
    UniProt: P59665

  • Chr Location
    8p23.1
  • Human Ortholog
    DEFA1B, defensin alpha 1B
  • Synonyms
    HNP-1, HP-1, HP1
  • Links
    NCBI Gene ID: 728358
    UniProt: P59665

  • Chr Location
    8p23.1; chr8:6996766-6999202 (-)  GRCh38
  • Human Ortholog
    DEFA3, defensin alpha 3
  • Synonyms
    DEF3, HNP-3, HNP3, HP-3, HP3
  • Links
    NCBI Gene ID: 1668
    UniProt: P59666

  • Chr Location
    8p23.1; chr8:7015869-7018359 (-)  GRCh38
  • Human Ortholog
    DEFA4, defensin alpha 4
  • Synonyms
    DEF4, HNP-4, HP-4, HP4
  • Links
    NCBI Gene ID: 1669
    UniProt: P12838

  • Chr Location
    8p23.1; chr8:6935820-6938306 (-)  GRCh38
  • Human Ortholog
    DEFA6, defensin alpha 6
  • Synonyms
    DEF6, HD-6
  • Links
    NCBI Gene ID: 1671
    UniProt: Q01524

  • Chr Location
    8p23.1; chr8:6924697-6926076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 665956 NCBI Gene Model | MGI Sequence Detail 979 C57BL/6J ±  kb
transcript NM_001177526 RefSeq | MGI Sequence Detail 351 C57BL/6  
polypeptide NP_001170997 RefSeq | MGI Sequence Detail 116 C57BL/6  
For the selected sequence
Protein
Information
less
Other
Accession IDs
less
MGI:6336193
References
more
  • Summaries
    All 10
    Phenotypes 4
  • Earliest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory