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Fam186b Gene Detail
Summary
  • Symbol
    Fam186b
  • Name
    family with sequence similarity 186, member B
  • Synonyms
    EG545136
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647604
    NCBI Gene: 545136
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99168899-99193769 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    652 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647604
 protein coding gene Chr15:99168899-99199656 (-)
129S1/SvImJ ENSMUSG00200051303
 protein coding gene Chr15:96358167-96396764 (-)
A/J ENSMUSG00195044905
 protein coding gene Chr15:96237605-96262686 (-)
AKR/J ENSMUSG00220043088
 protein coding gene Chr15:96245425-96270300 (-)
BALB/cJ ENSMUSG00180040030
 protein coding gene Chr15:96147960-96172833 (-)
C3H/HeJ ENSMUSG00175038045
 protein coding gene Chr15:96417639-96442713 (-)
C57BL/6NJ ENSMUSG00215048030
 protein coding gene Chr15:96207310-96232182 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020262
 protein coding gene Chr15:92974419-92991385 (-)
CAST/EiJ ENSTCUG00005044092
 protein coding gene Chr15:95688010-95712789 (-)
CBA/J ENSMUSG00210027222
 protein coding gene Chr15:96204941-96229806 (-)
DBA/2J ENSMUSG00185036827
 protein coding gene Chr15:96251844-96276717 (-)
FVB/NJ ENSMUSG00205045959
 protein coding gene Chr15:95956869-95981753 (-)
JF1/MsJ ENSUMUG00000038667
 protein coding gene Chr15:95705316-95730289 (-)
LP/J ENSMUSG00230038759
 protein coding gene Chr15:99581550-99620146 (-)
NOD/ShiLtJ ENSMUSG00190035890
 protein coding gene Chr15:96222711-96247590 (-)
NZO/HlLtJ ENSMUSG00225042866
 protein coding gene Chr15:99844253-99869125 (-)
PWK/PhJ ENSLUMG00010043810
 protein coding gene Chr15:95927495-95952370 (-)
SPRET/EiJ ENSMSPG00010049493
 protein coding gene Chr15:97728322-97744704 (-)
WSB/EiJ ENSIUOG00005038185
 protein coding gene Chr15:96333668-96358538 (-)



Homology
more
  • Human Ortholog
    FAM186B, family with sequence similarity 186 member B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM186B, family with sequence similarity 186 member B
  • Synonyms
    C12orf25
  • Links
    NCBI Gene ID: 84070
    UniProt: Q8IYM0

  • Chr Location
    12q13.12; chr12:49582873-49622758 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000078907 Ensembl Gene Model | MGI Sequence Detail 24871 C57BL/6J ±  kb
    transcript ENSMUST00000109100 Ensembl | MGI Sequence Detail 3187 Not Applicable  
    polypeptide ENSMUSP00000104728 Ensembl | MGI Sequence Detail 943 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR049146 FAM186A/B, C-terminal
      IPR049144 FAM186A/B, N-terminal
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 2
      Phenotypes 31
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory