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Cbr1b Gene Detail
Summary
  • Symbol
    Cbr1b
  • Name
    carbonyl reductase 1B
  • Synonyms
    Gm5678
Location &
Maps
more
  • Sequence Map
    Chr16:93424985-93427339 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 54.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646098
 protein coding gene Chr16:93424872-93427351 (+)
129S1/SvImJ ENSMUSG00200036980
 protein coding gene Chr16:90366289-90368699 (+)
A/J ENSMUSG00195027982
 protein coding gene Chr16:90124029-90126439 (+)
AKR/J ENSMUSG00220015606
 protein coding gene Chr16:90369325-90371736 (+)
BALB/cJ ENSMUSG00180013851
 protein coding gene Chr16:90198014-90200425 (+)
C3H/HeJ ENSMUSG00175015010
 protein coding gene Chr16:90535169-90537579 (+)
C57BL/6NJ ENSMUSG00215023435
 protein coding gene Chr16:90314776-90317130 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005018088
 protein coding gene Chr16:89885093-89887447 (+)
CBA/J ENSMUSG00210033342
 protein coding gene Chr16:90442707-90445117 (+)
DBA/2J ENSMUSG00185032767
 protein coding gene Chr16:90382099-90384509 (+)
FVB/NJ ENSMUSG00205020446
 protein coding gene Chr16:90161604-90164014 (+)
JF1/MsJ ENSUMUG00000015365
 protein coding gene Chr16:90531668-90534008 (+)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190024398
 protein coding gene Chr16:90350604-90353014 (+)
NZO/HlLtJ ENSMUSG00225030069
 protein coding gene Chr16:96029505-96031859 (+)
PWK/PhJ ENSLUMG00010013325
 protein coding gene Chr16:90170801-90173141 (+)
SPRET/EiJ ENSMSPG00010019818
 protein coding gene Chr16:91281023-91283312 (+)
WSB/EiJ ENSIUOG00005017930
 protein coding gene Chr16:90260472-90262826 (+)



Homology
more
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Synonyms
    CBR, hCBR1, PG-9-KR, SDR21C1
  • Links
    NCBI Gene ID: 873
    UniProt: P16152

  • Chr Location
    21q22.12; chr21:36069941-36073166 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      23
    • RefSeq
      1
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000082815 Ensembl Gene Model | MGI Sequence Detail 2355 C57BL/6J ±  kb
    transcript ENSMUST00000120115 Ensembl | MGI Sequence Detail 939 Not Applicable  
    polypeptide ENSMUSP00000147517 Ensembl | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
      1.1.1.184
    • InterPro Domains
      IPR045313 Carbonyl reductase [NADPH] 1-like
      IPR036291 NAD(P)-binding domain superfamily
      IPR002347 Short-chain dehydrogenase/reductase SDR
    Other
    Accession IDs
    less
    MGI:7484386
    References
    more
    • Summaries
      All 83
      Diseases 4
      Gene Ontology 8
      Phenotypes 69
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory