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Duxf4 Gene Detail
Summary
  • Symbol
    Duxf4
  • Name
    double homeobox family member 4
  • Synonyms
    Duxf4, Gm4981
Location &
Maps
more
  • Sequence Map
    Chr10:58070670-58072482 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645498
 protein coding gene Chr10:58070670-58072523 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017244
 protein coding gene Chr10:57321261-57322801 (-)
A/J MGP_AJ_G0017221
 protein coding gene Chr10:55666472-55667975 (-)
AKR/J MGP_AKRJ_G0017180
 protein coding gene Chr10:57124554-57126061 (-)
BALB/cJ MGP_BALBcJ_G0017182
 protein coding gene Chr10:55751980-55753758 (-)
C3H/HeJ MGP_C3HHeJ_G0017004
 protein coding gene Chr10:57029230-57030712 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017639
 protein coding gene Chr10:59417471-59419201 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0016576
 protein coding gene Chr10:56946077-56947648 (-)
CBA/J MGP_CBAJ_G0016976
 protein coding gene Chr10:61537877-61539642 (-)
DBA/2J MGP_DBA2J_G0017080
 protein coding gene Chr10:54998422-55000220 (-)
FVB/NJ MGP_FVBNJ_G0017076
 protein coding gene Chr10:54231412-54233467 (-)
LP/J MGP_LPJ_G0017157
 protein coding gene Chr10:57714265-57715853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017104
 protein coding gene Chr10:64094498-64095990 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017677
 protein coding gene Chr10:56925394-56928634 (-)
PWK/PhJ MGP_PWKPhJ_G0016358
 protein coding gene Chr10:54695106-54696331 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016143
 protein coding gene Chr10:56293765-56294902 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DUX4, double homeobox 4
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUX4, double homeobox 4
  • Synonyms
    DUX4L
  • Links
    NCBI Gene ID: 100288687
    UniProt: Q9UBX2

  • Chr Location
    chr4:190173774-190185942 (+)  GRCh38
  • Human Ortholog
    DUX4L2, double homeobox 4 like 2 (pseudogene)
  • Links
    NCBI Gene ID: 728410

  • Chr Location
    4q35.2; chr4:190091005-190092289 (+)  GRCh38
  • Human Ortholog
    DUX4L3, double homeobox 4 like 3 (pseudogene)
  • Links
    NCBI Gene ID: 653548

  • Chr Location
    4q35.2; chr4:190087705-190088989 (+)  GRCh38
  • Human Ortholog
    DUX4L4, double homeobox 4 like 4 (pseudogene)
  • Links
    NCBI Gene ID: 441056

  • Chr Location
    4q35.2; chr4:190081118-190082396 (+)  GRCh38
  • Human Ortholog
    DUX4L5, double homeobox 4 like 5 (pseudogene)
  • Links
    NCBI Gene ID: 653545

  • Chr Location
    4q35.2; chr4:190077818-190079102 (+)  GRCh38
  • Human Ortholog
    DUX4L6, double homeobox 4 like 6 (pseudogene)
  • Links
    NCBI Gene ID: 653544

  • Chr Location
    4q35.2; chr4:190074525-190075809 (+)  GRCh38
  • Human Ortholog
    DUX4L7, double homeobox 4 like 7 (pseudogene)
  • Links
    NCBI Gene ID: 653543

  • Chr Location
    4q35.2; chr4:190071232-190072516 (+)  GRCh38
  • Human Ortholog
    DUX4L9, double homeobox 4 like 9 (pseudogene)
  • Synonyms
    DUX4C
  • Links
    NCBI Gene ID: 100288711

  • Chr Location
    chr4:190021169-190022665 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    9 phenotype references
Mice homozygous for null alleles in each genes of the Dux cluster exhibit delayed zygotic gene activation and decreased development potential of embryos.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 245263 NCBI Gene Model | MGI Sequence Detail 1813 C57BL/6J ±  kb
transcript NM_001034869 RefSeq | MGI Sequence Detail 1813 C57BL/6  
polypeptide NP_001030041 RefSeq | MGI Sequence Detail 291 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001356 Homeobox domain
    IPR051306 Homeobox domain-containing regulator
    IPR009057 Homeobox-like domain superfamily
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
Other
Accession IDs
less
MGI:7539550
References
more
  • Summaries
    All 18
    Phenotypes 9
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:353213 Yang G, et al., Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Cell Stem Cell. 2021 Jan 7;28(1):150-163.e5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory