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Alkal1 Gene Detail
Summary
  • Symbol
    Alkal1
  • Name
    ALK and LTK ligand 1
  • Synonyms
    Augbeta, Augmentor beta, EG620393, Fam150a
Location &
Maps
more
  • Sequence Map
    Chr1:6429555-6464955 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1298 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645495
 protein coding gene Chr1:6429442-6464955 (+)
129S1/SvImJ ENSMUSG00200002081
 protein coding gene Chr1:3819685-3855197 (+)
A/J ENSMUSG00195002683
 protein coding gene Chr1:3639464-3674702 (+)
AKR/J ENSMUSG00220003509
 protein coding gene Chr1:3697355-3732875 (+)
BALB/cJ ENSMUSG00180008977
 protein coding gene Chr1:3716821-3752062 (+)
C3H/HeJ ENSMUSG00175000292
 protein coding gene Chr1:3584452-3625147 (+)
C57BL/6NJ ENSMUSG00215004124
 protein coding gene Chr1:3620139-3655655 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013931
 protein coding gene Chr1:3003689-3036839 (+)
CAST/EiJ ENSTCUG00005002062
 protein coding gene Chr1:3975987-4012653 (+)
CBA/J ENSMUSG00210001751
 protein coding gene Chr1:3504890-3540178 (+)
DBA/2J ENSMUSG00185004500
 protein coding gene Chr1:4523932-4559209 (+)
FVB/NJ ENSMUSG00205005112
 protein coding gene Chr1:3778680-3813923 (+)
JF1/MsJ ENSUMUG00000003130
 protein coding gene Chr1:3779835-3814020 (+)
LP/J ENSMUSG00230001940
 protein coding gene Chr1:4526792-4562303 (+)
NOD/ShiLtJ ENSMUSG00190001122
 protein coding gene Chr1:3644085-3679599 (+)
NZO/HlLtJ ENSMUSG00225000083
 protein coding gene Chr1:7914138-7949378 (+)
PWK/PhJ ENSLUMG00010002234
 protein coding gene Chr1:3359484-3393610 (+)
SPRET/EiJ ENSMSPG00010013951
 protein coding gene Chr1:3979936-4020141 (+)
WSB/EiJ ENSIUOG00005010260
 protein coding gene Chr1:3613491-3648754 (+)



Homology
more
  • Human Ortholog
    ALKAL1, ALK and LTK ligand 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKAL1, ALK and LTK ligand 1
  • Synonyms
    AUGA, AUGB, FAM150A, UNQ9433
  • Links
    NCBI Gene ID: 389658
    UniProt: Q6UXT8

  • Chr Location
    8q11.23; chr8:52534037-52565430 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    5 phenotype references
Homozygous deletion of this gene results in normal body weight curves with no apparent thinness phenotype on a standard chow diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    1
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 620393 NCBI Gene Model | MGI Sequence Detail 35401 C57BL/6J ±  kb
transcript NM_001195732 RefSeq | MGI Sequence Detail 858 C57BL/6  
polypeptide J3QPP8 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:5897449
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:385781 Tang T, et al., Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons. J Neurosci. 2026 Apr 8;46(14)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory