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Rgs21 Gene Detail
Summary
  • Symbol
    Rgs21
  • Name
    regulator of G-protein signalling 21
  • Synonyms
    EG624910
Location &
Maps
more
  • Sequence Map
    Chr1:144392388-144443185 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1309 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645243
 protein coding gene Chr1:144392386-144443405 (-)
129S1/SvImJ ENSMUSG00200007148
 protein coding gene Chr1:141862650-141895703 (-)
A/J ENSMUSG00195015617
 protein coding gene Chr1:141190567-141223328 (-)
AKR/J ENSMUSG00220002684
 protein coding gene Chr1:140938176-140971118 (-)
BALB/cJ ENSMUSG00180011329
 protein coding gene Chr1:141398925-141431876 (-)
C3H/HeJ ENSMUSG00175006449
 protein coding gene Chr1:141407723-141440778 (-)
C57BL/6NJ ENSMUSG00215009397
 protein coding gene Chr1:141328299-141361250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014681
 protein coding gene Chr1:135711938-135763327 (-)
CAST/EiJ ENSTCUG00005013027
 protein coding gene Chr1:140117784-140150819 (-)
CBA/J ENSMUSG00210014253
 protein coding gene Chr1:141328404-141361463 (-)
DBA/2J ENSMUSG00185006933
 protein coding gene Chr1:145647518-145680471 (-)
FVB/NJ ENSMUSG00205002199
 protein coding gene Chr1:140544005-140577062 (-)
JF1/MsJ ENSUMUG00000011767
 protein coding gene Chr1:144948751-144981795 (-)
LP/J ENSMUSG00230000092
 protein coding gene Chr1:145160965-145193920 (-)
NOD/ShiLtJ ENSMUSG00190002011
 protein coding gene Chr1:141162069-141195124 (-)
NZO/HlLtJ ENSMUSG00225000055
 protein coding gene Chr1:148921274-148954331 (-)
PWK/PhJ ENSLUMG00010001779
 protein coding gene Chr1:140242185-140275161 (-)
SPRET/EiJ ENSMSPG00010012211
 protein coding gene Chr1:143212572-143243520 (-)
WSB/EiJ ENSIUOG00005026903
 protein coding gene Chr1:140739035-140772069 (-)



Homology
more
  • Human Ortholog
    RGS21, regulator of G protein signaling 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS21, regulator of G protein signaling 21
  • Links
    NCBI Gene ID: 431704
    UniProt: Q2M5E4

  • Chr Location
    1q31.2; chr1:192316992-192367285 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice show reduced aversion to bitter taste and reduced preference towards sweeteners, umami taste, and salty taste.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 624910 NCBI Gene Model | MGI Sequence Detail 50798 C57BL/6J ±  kb
    transcript NM_001290269 RefSeq | MGI Sequence Detail 2721 C57BL/6  
    polypeptide NP_001277198 RefSeq | MGI Sequence Detail 152 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 16
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:193014 Cohen SP, et al., Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J Biol Chem. 2012 Dec 7;287(50):41706-19
    • Latest
      J:351907 Schroer AB, et al., The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21). Chem Senses. 2021 Jan 1;46
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory