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Defb23 Gene Detail
Summary
  • Symbol
    Defb23
  • Name
    defensin beta 23
  • Synonyms
    EG629114
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644405
    NCBI Gene: 629114
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152300975-152306540 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644405
 protein coding gene Chr2:152300914-152306540 (-)
129S1/SvImJ ENSMUSG00200028591
 protein coding gene Chr2:149200870-149206450 (-)
A/J ENSMUSG00195017253
 protein coding gene Chr2:149484374-149490678 (-)
AKR/J ENSMUSG00220045158
 protein coding gene Chr2:148809634-148815199 (-)
BALB/cJ ENSMUSG00180038977
 protein coding gene Chr2:148971104-148976679 (-)
C3H/HeJ ENSMUSG00175040100
 protein coding gene Chr2:149717339-149722912 (-)
C57BL/6NJ ENSMUSG00215018857
 protein coding gene Chr2:149144311-149149876 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024456
 protein coding gene Chr2:144334861-144340589 (-)
CAST/EiJ ENSTCUG00005039163
 protein coding gene Chr2:148068782-148074344 (-)
CBA/J ENSMUSG00210044080
 protein coding gene Chr2:149653829-149659407 (-)
DBA/2J ENSMUSG00185045741
 protein coding gene Chr2:149304329-149309891 (-)
FVB/NJ ENSMUSG00205023340
 protein coding gene Chr2:148401081-148406648 (-)
JF1/MsJ ENSUMUG00000045559
 protein coding gene Chr2:148973255-148979245 (-)
LP/J ENSMUSG00230032351
 protein coding gene Chr2:150953279-150958859 (-)
NOD/ShiLtJ ENSMUSG00190033014
 protein coding gene Chr2:149072577-149078680 (-)
NZO/HlLtJ ENSMUSG00225004432
 protein coding gene Chr2:158992477-158998047 (-)
PWK/PhJ ENSLUMG00010037976
 protein coding gene Chr2:148942273-148948345 (-)
SPRET/EiJ ENSMSPG00010028265
 protein coding gene Chr2:151668526-151674113 (-)
WSB/EiJ ENSIUOG00005046779
 protein coding gene Chr2:148808414-148813965 (-)



Homology
more
  • Human Ortholog
    DEFB129, defensin beta 129
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB129, defensin beta 129
  • Synonyms
    bA530N10.3, C20orf87, DEFB-29, DEFB29, hBD-29
  • Links
    NCBI Gene ID: 140881
    UniProt: Q9H1M3

  • Chr Location
    20p13; chr20:227258-229886 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Defb23
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    5 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074681 Ensembl Gene Model | MGI Sequence Detail 5566 C57BL/6J ±  kb
transcript ENSMUST00000099206 Ensembl | MGI Sequence Detail 624 Not Applicable  
polypeptide ENSMUSP00000096812 Ensembl | MGI Sequence Detail 166 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR025933 Beta-defensin domain
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:101568 Patil AA, et al., Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005 Sep 21;23(1):5-17
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory