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Tagap Gene Detail
Summary
  • Symbol
    Tagap
  • Name
    T cell activation Rho GTPase activating protein
  • Synonyms
    Tcd-1, Tcd1, Tcd1a, tcs-1, tcs1, TRD
  • Feature Type
    protein coding gene
  • IDs
    MGI:3615484
    NCBI Gene: 72536
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:8144832-8153729 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3615484
 protein coding gene Chr17:8144832-8153729 (+)
129S1/SvImJ ENSMUSG00200033556
 protein coding gene Chr17:3682083-3690705 (-)
A/J ENSMUSG00195023419
 protein coding gene Chr17:4598784-4607681 (+)
AKR/J ENSMUSG00220024972
 protein coding gene Chr17:4653339-4661953 (+)
BALB/cJ ENSMUSG00180020998
 protein coding gene Chr17:4244233-4253131 (+)
C3H/HeJ ENSMUSG00175030505
 protein coding gene Chr17:4389336-4398233 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021037
 protein coding gene Chr17:3471875-3480813 (-)
CAST/EiJ ENSTCUG00005020377
 protein coding gene Chr17:3901163-3910061 (-)
CBA/J ENSMUSG00210034072
 protein coding gene Chr17:4056174-4065071 (+)
DBA/2J ENSMUSG00185022386
 protein coding gene Chr17:5148813-5157710 (+)
FVB/NJ no annotation
JF1/MsJ no annotation
LP/J ENSMUSG00230031782
 protein coding gene Chr17:6557138-6565743 (+)
NOD/ShiLtJ ENSMUSG00190029979
 protein coding gene Chr17:4363547-4372444 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Synonyms
    ARHGAP47, FKSG15, IDDM21, TAGAP1
  • Links
    NCBI Gene ID: 117289
    UniProt: Q8N103

  • Chr Location
    6q25.3; chr6:159034481-159095823 (-)  GRCh38
Human Diseases
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  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from multigenic genotypes
    378 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72536 NCBI Gene Model | MGI Sequence Detail 8898 C57BL/6J ±  kb
transcript NM_145968 RefSeq | MGI Sequence Detail 3076 Not Specified  
polypeptide B2RWW0 UniProt | EBI | MGI Sequence Detail 714 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR047886 ARHGAP20-like, RhoGAP domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
  • GlyGen
    B2RWW0 5 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14737, MGD-MRK-14742, MGD-MRK-14931, MGD-MRK-14934, MGI:98499
References
more
  • Summaries
    All 406
    Diseases 6
    Gene Ontology 3
    Phenotypes 378
  • Earliest
    J:6915 Klein J, et al., H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17. Immunogenetics. 1982;16(4):285-317
  • Latest
    J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory